Literature DB >> 29878131

The Makona Variant of Ebola Virus Is Highly Lethal to Immunocompromised Mice and Immunocompetent Ferrets.

Gary Wong1,2,3,4, Anders Leung1,3, Shihua He1, Wenguang Cao1,3, Marc-Antoine De La Vega5, Bryan D Griffin1,3, Geoff Soule1, Gary P Kobinger5, Darwyn Kobasa1,3, Xiangguo Qiu1,3.   

Abstract

During 2013-2016, a novel isolate of Ebola virus (EBOV-Makona) caused an epidemic in West Africa. The virus was distinct from known EBOV strains (EBOV-Kikwit and EBOV-Mayinga), which were responsible for previous outbreaks in Central Africa. To investigate the pathogenicity of EBOV-Makona, we engineered and rescued an early isolate (H.sapiens-wt/GIN/2014/Makona-Gueckedou-C07, called rgEBOV-C07) using an updated reverse-genetics system. rgEBOV-C07 was found to be highly pathogenic in both the knockout mouse and ferret models, with median lethal dose values of 0.078 and 0.015 plaque-forming units, respectively. Therefore, these animals are appropriate for screening potential countermeasures against EBOV-Makona without the need for species adaptation.

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Year:  2018        PMID： 29878131      PMCID： PMC6249576          DOI： 10.1093/infdis/jiy141

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  13 in total

1.  Reverse genetics demonstrates that proteolytic processing of the Ebola virus glycoprotein is not essential for replication in cell culture.

Authors:  Gabriele Neumann; Heinz Feldmann; Shinji Watanabe; Igor Lukashevich; Yoshihiro Kawaoka
Journal:  J Virol       Date:  2002-01       Impact factor: 5.103

2.  Emergence of Zaire Ebola virus disease in Guinea.

Authors:  Sylvain Baize; Delphine Pannetier; Lisa Oestereich; Toni Rieger; Lamine Koivogui; N'Faly Magassouba; Barrè Soropogui; Mamadou Saliou Sow; Sakoba Keïta; Hilde De Clerck; Amanda Tiffany; Gemma Dominguez; Mathieu Loua; Alexis Traoré; Moussa Kolié; Emmanuel Roland Malano; Emmanuel Heleze; Anne Bocquin; Stephane Mély; Hervé Raoul; Valérie Caro; Dániel Cadar; Martin Gabriel; Meike Pahlmann; Dennis Tappe; Jonas Schmidt-Chanasit; Benido Impouma; Abdoul Karim Diallo; Pierre Formenty; Michel Van Herp; Stephan Günther
Journal:  N Engl J Med       Date:  2014-04-16       Impact factor: 91.245

3.  Ferrets Infected with Bundibugyo Virus or Ebola Virus Recapitulate Important Aspects of Human Filovirus Disease.

Authors:  Robert Kozak; Shihua He; Andrea Kroeker; Marc-Antoine de La Vega; Jonathan Audet; Gary Wong; Chantel Urfano; Kym Antonation; Carissa Embury-Hyatt; Gary P Kobinger; Xiangguo Qiu
Journal:  J Virol       Date:  2016-09-29       Impact factor: 5.103

4.  Development of a reverse genetics system to generate a recombinant Ebola virus Makona expressing a green fluorescent protein.

Authors:  César G Albariño; Lisa Wiggleton Guerrero; Michael K Lo; Stuart T Nichol; Jonathan S Towner
Journal:  Virology       Date:  2015-06-27       Impact factor: 3.616

5.  A mouse model for evaluation of prophylaxis and therapy of Ebola hemorrhagic fever.

Authors:  M Bray; K Davis; T Geisbert; C Schmaljohn; J Huggins
Journal:  J Infect Dis       Date:  1998-09       Impact factor: 5.226

6.  Pathogenicity Comparison Between the Kikwit and Makona Ebola Virus Variants in Rhesus Macaques.

Authors:  Gary Wong; Xiangguo Qiu; Marc-Antoine de La Vega; Lisa Fernando; Haiyan Wei; Alexander Bello; Hugues Fausther-Bovendo; Jonathan Audet; Andrea Kroeker; Robert Kozak; Kaylie Tran; Shihua He; Kevin Tierney; Geoff Soule; Estella Moffat; Stephan Günther; George F Gao; Jim Strong; Carissa Embury-Hyatt; Gary Kobinger
Journal:  J Infect Dis       Date:  2016-09-19       Impact factor: 5.226

7.  Delayed Disease Progression in Cynomolgus Macaques Infected with Ebola Virus Makona Strain.

Authors:  Andrea Marzi; Friederike Feldmann; Patrick W Hanley; Dana P Scott; Stephan Günther; Heinz Feldmann
Journal:  Emerg Infect Dis       Date:  2015-10       Impact factor: 6.883

8.  The Domestic Ferret (Mustela putorius furo) as a Lethal Infection Model for 3 Species of Ebolavirus.

Authors:  Robert W Cross; Chad E Mire; Viktoriya Borisevich; Joan B Geisbert; Karla A Fenton; Thomas W Geisbert
Journal:  J Infect Dis       Date:  2016-05-24       Impact factor: 5.226

Review 9.  Flavivirus reverse genetic systems, construction techniques and applications: a historical perspective.

Authors:  Fabien Aubry; Antoine Nougairède; Ernest A Gould; Xavier de Lamballerie
Journal:  Antiviral Res       Date:  2014-12-12       Impact factor: 5.970

10.  Real-time, portable genome sequencing for Ebola surveillance.

Authors:  Joshua Quick; Nicholas J Loman; Sophie Duraffour; Jared T Simpson; Ettore Severi; Lauren Cowley; Joseph Akoi Bore; Raymond Koundouno; Gytis Dudas; Amy Mikhail; Nobila Ouédraogo; Babak Afrough; Amadou Bah; Jonathan Hj Baum; Beate Becker-Ziaja; Jan-Peter Boettcher; Mar Cabeza-Cabrerizo; Alvaro Camino-Sanchez; Lisa L Carter; Juiliane Doerrbecker; Theresa Enkirch; Isabel Graciela García Dorival; Nicole Hetzelt; Julia Hinzmann; Tobias Holm; Liana Eleni Kafetzopoulou; Michel Koropogui; Abigail Kosgey; Eeva Kuisma; Christopher H Logue; Antonio Mazzarelli; Sarah Meisel; Marc Mertens; Janine Michel; Didier Ngabo; Katja Nitzsche; Elisa Pallash; Livia Victoria Patrono; Jasmine Portmann; Johanna Gabriella Repits; Natasha Yasmin Rickett; Andrea Sachse; Katrin Singethan; Inês Vitoriano; Rahel L Yemanaberhan; Elsa G Zekeng; Racine Trina; Alexander Bello; Amadou Alpha Sall; Ousmane Faye; Oumar Faye; N'Faly Magassouba; Cecelia V Williams; Victoria Amburgey; Linda Winona; Emily Davis; Jon Gerlach; Franck Washington; Vanessa Monteil; Marine Jourdain; Marion Bererd; Alimou Camara; Hermann Somlare; Abdoulaye Camara; Marianne Gerard; Guillaume Bado; Bernard Baillet; Déborah Delaune; Koumpingnin Yacouba Nebie; Abdoulaye Diarra; Yacouba Savane; Raymond Bernard Pallawo; Giovanna Jaramillo Gutierrez; Natacha Milhano; Isabelle Roger; Christopher J Williams; Facinet Yattara; Kuiama Lewandowski; Jamie Taylor; Philip Rachwal; Daniel Turner; Georgios Pollakis; Julian A Hiscox; David A Matthews; Matthew K O'Shea; Andrew McD Johnston; Duncan Wilson; Emma Hutley; Erasmus Smit; Antonino Di Caro; Roman Woelfel; Kilian Stoecker; Erna Fleischmann; Martin Gabriel; Simon A Weller; Lamine Koivogui; Boubacar Diallo; Sakoba Keita; Andrew Rambaut; Pierre Formenty; Stephan Gunther; Miles W Carroll
Journal:  Nature       Date:  2016-02-03       Impact factor: 69.504
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  10 in total

1.  Comparison of Aerosol Stability of Different Variants of Ebola Virus and Marburg Virus and Virulence of Aerosolised Ebola Virus in an Immune-Deficient Mouse.

Authors:  Sophie J Smither; Lin S Eastaugh; Mark S Lever
Journal:  Viruses       Date:  2022-04-09       Impact factor: 5.818

2.  Ebola Virus Encodes Two microRNAs in Huh7-Infected Cells.

Authors:  Idrissa Diallo; Zeinab Husseini; Sara Guellal; Elodie Vion; Jeffrey Ho; Robert A Kozak; Gary P Kobinger; Patrick Provost
Journal:  Int J Mol Sci       Date:  2022-05-07       Impact factor: 6.208

3.  Kikwit Ebola Virus Disease Progression in the Rhesus Monkey Animal Model.

Authors:  Richard S Bennett; James Logue; David X Liu; Rebecca J Reeder; Krisztina B Janosko; Donna L Perry; Timothy K Cooper; Russell Byrum; Danny Ragland; Marisa St Claire; Ricky Adams; Tracey L Burdette; Tyler M Brady; Kyra Hadley; M Colin Waters; Rebecca Shim; William Dowling; Jing Qin; Ian Crozier; Peter B Jahrling; Lisa E Hensley
Journal:  Viruses       Date:  2020-07-14       Impact factor: 5.048

4.  Filovirus Virulence in Interferon α/β and γ Double Knockout Mice, and Treatment with Favipiravir.

Authors:  Jason E Comer; Olivier Escaffre; Natasha Neef; Trevor Brasel; Terry L Juelich; Jennifer K Smith; Jeanon Smith; Birte Kalveram; David D Perez; Shane Massey; Lihong Zhang; Alexander N Freiberg
Journal:  Viruses       Date:  2019-02-03       Impact factor: 5.048

5.  Pathogenicity and Virulence of Ebolaviruses with Species- and Variant-specificity.

Authors:  Satoko Yamaoka; Hideki Ebihara
Journal:  Virulence       Date:  2021-12       Impact factor: 5.882

6.  Modeling Ebola Virus Transmission Using Ferrets.

Authors:  Marc-Antoine de La Vega; Geoff Soule; Kaylie N Tran; Kevin Tierney; Shihua He; Gary Wong; Xiangguo Qiu; Gary P Kobinger
Journal:  mSphere       Date:  2018-10-31       Impact factor: 4.389

7.  Naturally Occurring Single Mutations in Ebola Virus Observably Impact Infectivity.

Authors:  Gary Wong; Shihua He; Anders Leung; Wenguang Cao; Yuhai Bi; Zirui Zhang; Wenjun Zhu; Liang Wang; Yuhui Zhao; Keding Cheng; Di Liu; Wenjun Liu; Darwyn Kobasa; George F Gao; Xiangguo Qiu
Journal:  J Virol       Date:  2018-12-10       Impact factor: 5.103

8.  Establishment of an RNA polymerase II-driven reverse genetics system for Nipah virus strains from Malaysia and Bangladesh.

Authors:  Bryan D Griffin; Anders Leung; Mable Chan; Bryce M Warner; Charlene Ranadheera; Kevin Tierney; Jonathan Audet; Kathy L Frost; David Safronetz; Carissa Embury-Hyatt; Stephanie A Booth; Darwyn Kobasa
Journal:  Sci Rep       Date:  2019-08-01       Impact factor: 4.379

9.  Generation and Characterization of a Mouse-Adapted Makona Variant of Ebola Virus.

Authors:  Mable Chan; Anders Leung; Bryan D Griffin; Robert Vendramelli; Nikesh Tailor; Kevin Tierney; Jonathan Audet; Darwyn Kobasa
Journal:  Viruses       Date:  2019-10-26       Impact factor: 5.048

10.  Mucosal Challenge Ferret Models of Ebola Virus Disease.

Authors:  Trevor Brasel; Jason E Comer; Shane Massey; Jeanon Smith; Jennifer Smith; Matthew Hyde; Andrew Kocsis; Melicia Gainey; Nancy Niemuth; Cheryl Triplett; Thomas Rudge
Journal:  Pathogens       Date:  2021-03-04
  10 in total

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