Buyun Liu1, Yangbo Sun1, Hans-Joachim Lehmler2,3, Wei Bao1,3,4,5,6. 1. Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, Iowa, USA. 2. Department of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa, USA. 3. Environmental Health Sciences Research Center, University of Iowa, Iowa City, Iowa, USA. 4. Obesity Research and Education Initiative, University of Iowa, Iowa City, Iowa, USA. 5. Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA. 6. Center for Global and Regional Environmental Research, University of Iowa, Iowa City, Iowa, USA.
Abstract
BACKGROUND: Animal studies indicate that chronic exposure to certain tin compounds induces pancreatic islet cell apoptosis and glucose intolerance. However, little is known about the health effects of environmental tin exposure in humans. Therefore, we evaluated the association of tin exposure with diabetes in a nationally representative sample of US adults. METHODS: We used data from a nationally representative population (n = 3371) in the National Health and Nutrition Examination Survey 2011-14. Diabetes (n = 605) was defined as self-reported physician's diagnosis, HbA1c ≥6.5%, fasting plasma glucose ≥126 mg/dL, or 2-h plasma glucose ≥200 mg/dL. Tin concentrations in urine samples were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) of diabetes and 95% confidence intervals (CIs). RESULTS: Urinary tin concentrations were higher in individuals with diabetes (weighted median 0.58 μg/L) than those without diabetes (0.39 μg/L). After adjustment for urinary creatinine and other diabetes risk factors, the OR of diabetes comparing the highest with lowest quartile of urinary tin concentrations was 1.6 (95% CI 1.0-2.6; Ptrend = 0.02). CONCLUSIONS: Environmental tin exposure was positively and significantly associated with diabetes in US adults.
BACKGROUND: Animal studies indicate that chronic exposure to certain tin compounds induces pancreatic islet cell apoptosis and glucose intolerance. However, little is known about the health effects of environmental tin exposure in humans. Therefore, we evaluated the association of tin exposure with diabetes in a nationally representative sample of US adults. METHODS: We used data from a nationally representative population (n = 3371) in the National Health and Nutrition Examination Survey 2011-14. Diabetes (n = 605) was defined as self-reported physician's diagnosis, HbA1c ≥6.5%, fasting plasma glucose ≥126 mg/dL, or 2-h plasma glucose ≥200 mg/dL. Tin concentrations in urine samples were determined by inductively coupled plasma mass spectrometry. Logistic regression with sample weights was used to estimate the odds ratios (ORs) of diabetes and 95% confidence intervals (CIs). RESULTS: Urinary tin concentrations were higher in individuals with diabetes (weighted median 0.58 μg/L) than those without diabetes (0.39 μg/L). After adjustment for urinary creatinine and other diabetes risk factors, the OR of diabetes comparing the highest with lowest quartile of urinary tin concentrations was 1.6 (95% CI 1.0-2.6; Ptrend = 0.02). CONCLUSIONS: Environmental tin exposure was positively and significantly associated with diabetes in US adults.
Authors: Bruno D Bertuloso; Priscila L Podratz; Eduardo Merlo; Julia F P de Araújo; Leandro C F Lima; Emilio C de Miguel; Leticia N de Souza; Agata L Gava; Miriane de Oliveira; Leandro Miranda-Alves; Maria T W D Carneiro; Celia R Nogueira; Jones B Graceli Journal: Toxicol Lett Date: 2015-03-25 Impact factor: 4.372
Authors: Dana B Barr; Lynn C Wilder; Samuel P Caudill; Amanda J Gonzalez; Lance L Needham; James L Pirkle Journal: Environ Health Perspect Date: 2005-02 Impact factor: 9.031
Authors: Christel Gumy; Charlie Chandsawangbhuwana; Anna A Dzyakanchuk; Denise V Kratschmar; Michael E Baker; Alex Odermatt Journal: PLoS One Date: 2008-10-28 Impact factor: 3.240
Authors: Jerrold J Heindel; Sarah Howard; Keren Agay-Shay; Juan P Arrebola; Karine Audouze; Patrick J Babin; Robert Barouki; Amita Bansal; Etienne Blanc; Matthew C Cave; Saurabh Chatterjee; Nicolas Chevalier; Mahua Choudhury; David Collier; Lisa Connolly; Xavier Coumoul; Gabriella Garruti; Michael Gilbertson; Lori A Hoepner; Alison C Holloway; George Howell; Christopher D Kassotis; Mathew K Kay; Min Ji Kim; Dominique Lagadic-Gossmann; Sophie Langouet; Antoine Legrand; Zhuorui Li; Helene Le Mentec; Lars Lind; P Monica Lind; Robert H Lustig; Corinne Martin-Chouly; Vesna Munic Kos; Normand Podechard; Troy A Roepke; Robert M Sargis; Anne Starling; Craig R Tomlinson; Charbel Touma; Jan Vondracek; Frederick Vom Saal; Bruce Blumberg Journal: Biochem Pharmacol Date: 2022-04-05 Impact factor: 6.100
Authors: Manuel Gadogbe; Wei Bao; Brian R Wels; Suzie Y Dai; Donna A Santillan; Mark K Santillan; Hans-Joachim Lehmler Journal: J Environ Sci Health A Tox Hazard Subst Environ Eng Date: 2019-05-06 Impact factor: 2.269
Authors: Richard E Frye; Janet Cakir; Shannon Rose; Leanna Delhey; Sirish C Bennuri; Marie Tippett; Raymond F Palmer; Christine Austin; Paul Curtin; Manish Arora Journal: Transl Psychiatry Date: 2020-07-07 Impact factor: 6.222
Authors: Xin Wang; Carrie A Karvonen-Gutierrez; William H Herman; Bhramar Mukherjee; Siobán D Harlow; Sung Kyun Park Journal: BMJ Open Diabetes Res Care Date: 2020-07