Adil Doğan1, Nuray Bayar Muluk2,3, Mehmet Hamdi Şahan4, Neşe Asal4, Mikail Inal4, Ufuk Ergün5. 1. Faculty of Medicine, Radiology Department, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. 2. Faculty of Medicine, ENT Department, Kırıkkale University, Kırıkkale, Turkey. nurayb@hotmail.com. 3. Birlik Mahallesi, Zirvekent 2. Etap Sitesi, C-3 blok, No: 6-3/43, 06610, Çankaya/Ankara, Turkey. nurayb@hotmail.com. 4. Faculty of Medicine, Radiology Department, Kırıkkale University, Kırıkkale, Turkey. 5. Faculty of Medicine, Neurology Department, Kırıkkale University, Kırıkkale, Turkey.
Abstract
OBJECTIVES: To compare the measurements of olfactory bulb volume and olfactory sulcus depth in patients with migraine and a control group. METHODS: The study included the cranial MRI (1.5 T) images of 200 adults diagnosed with migraine and a control group of 100 subjects without migraine. The control group mainly consisted of the patients with non-migraneous headache. The measurements were obtained from coronal T2-weighted images for standard olfactory bulb (OB) volume and olfactory sulcus (OS) depth. RESULTS: The OB volume and OS depth values were lower in the migraine group than in the control group. In the migraine group, left OB volume of the males was significantly lower than those of the females. In both the migraine and control groups separately, the left-side OB volume values and the right side OS depth values were significantly greater than those of the contralateral side. There were positive correlations between right and left OB volume, and right and left OS depth values. No change was seen in OB volume and OS depth values according to gender. In older patients, a decrease was determined in the right and left OB volume, and the left-side OS depth values. There was a negative correlation between osmophobia and OB volume values. In migraine patients with osmophobia, the OB volume values were significantly decreased. CONCLUSION: OB volume values were lower in migraine patients. When osmophobia was present, the OB volume was lower than that of the non-osmophobia migraine patients. Olfactory function monitoring with olfactory tests and olfactory volume monitoring on MRI can be recommended for all migraine patients to diagnose olfactory dysfunction earlier, especially those with osmophobia. Because their OB volume values were detected as lower than those of the migraine patients without osmophobia, it may be thought that blood flow changes and osmophobia may affect the olfactory bulb volume shrinkage in migraine patients.
OBJECTIVES: To compare the measurements of olfactory bulb volume and olfactory sulcus depth in patients with migraine and a control group. METHODS: The study included the cranial MRI (1.5 T) images of 200 adults diagnosed with migraine and a control group of 100 subjects without migraine. The control group mainly consisted of the patients with non-migraneous headache. The measurements were obtained from coronal T2-weighted images for standard olfactory bulb (OB) volume and olfactory sulcus (OS) depth. RESULTS: The OB volume and OS depth values were lower in the migraine group than in the control group. In the migraine group, left OB volume of the males was significantly lower than those of the females. In both the migraine and control groups separately, the left-side OB volume values and the right side OS depth values were significantly greater than those of the contralateral side. There were positive correlations between right and left OB volume, and right and left OS depth values. No change was seen in OB volume and OS depth values according to gender. In older patients, a decrease was determined in the right and left OB volume, and the left-side OS depth values. There was a negative correlation between osmophobia and OB volume values. In migrainepatients with osmophobia, the OB volume values were significantly decreased. CONCLUSION: OB volume values were lower in migrainepatients. When osmophobia was present, the OB volume was lower than that of the non-osmophobia migrainepatients. Olfactory function monitoring with olfactory tests and olfactory volume monitoring on MRI can be recommended for all migrainepatients to diagnose olfactory dysfunction earlier, especially those with osmophobia. Because their OB volume values were detected as lower than those of the migrainepatients without osmophobia, it may be thought that blood flow changes and osmophobia may affect the olfactory bulb volume shrinkage in migrainepatients.
Authors: A Mueller; N D Abolmaali; A R Hakimi; T Gloeckler; B Herting; H Reichmann; T Hummel Journal: J Neural Transm (Vienna) Date: 2005-02-15 Impact factor: 3.575
Authors: Philippe Rombaux; André Mouraux; Bernard Bertrand; Georges Nicolas; Thierry Duprez; Thomas Hummel Journal: Laryngoscope Date: 2006-03 Impact factor: 3.325
Authors: Philippe Rombaux; Heike Weitz; Andre Mouraux; George Nicolas; Bernard Bertrand; Thierry Duprez; Thomas Hummel Journal: Arch Otolaryngol Head Neck Surg Date: 2006-12
Authors: Marco Aurélio Fornazieri; Anibal Rodrigues Neto; Fabio de Rezende Pinna; Fabio Henrique Gobbi Porto; Paulo de Lima Navarro; Richard Louis Voegels; Richard L Doty Journal: Headache Date: 2016-10-25 Impact factor: 5.887
Authors: G Kobal; L Klimek; M Wolfensberger; H Gudziol; A Temmel; C M Owen; H Seeber; E Pauli; T Hummel Journal: Eur Arch Otorhinolaryngol Date: 2000 Impact factor: 2.503