Literature DB >> 2987521

Cervical papillomaviruses segregate within morphologically distinct precancerous lesions.

C P Crum, M Mitao, R U Levine, S Silverstein.   

Abstract

We combined molecular hybridization and histological analysis of 58 biopsy samples from the uterine cervix to correlate the presence of certain strains of human papillomaviruses (HPVs) with specific pathological changes. HPV sequences were frequently detected (85%) in biopsies that contained a broad spectrum of precancerous changes. The presence of HPV 16 correlated strongly with precancers that exhibited morphological aberrations commonly found in invasive carcinomas and precancers that have a high risk of progression. This association underscores the potential importance of HPV type 16 in the genesis of genital cancers and emphasizes the value of histological analysis for detecting potentially oncogenic HPVs.

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Year:  1985        PMID： 2987521      PMCID： PMC254851     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  18 in total

1.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

2.  Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.

Authors:  G M Wahl; M Stern; G R Stark
Journal:  Proc Natl Acad Sci U S A       Date:  1979-08       Impact factor: 11.205

3.  A rapid alkaline extraction procedure for screening recombinant plasmid DNA.

Authors:  H C Birnboim; J Doly
Journal:  Nucleic Acids Res       Date:  1979-11-24       Impact factor: 16.971

Review 4.  Cervical intraepithelial neoplasia.

Authors:  R M Richart
Journal:  Pathol Annu       Date:  1973

5.  A membrane-filter technique for the detection of complementary DNA.

Authors:  D T Denhardt
Journal:  Biochem Biophys Res Commun       Date:  1966-06-13       Impact factor: 3.575

6.  Detection and characterization of viral genomes and search for tumoral antigens in two hamster cell lines derived from tumors induced by bovine papillomavirus type 1.

Authors:  F Breitburd; M Favre; R Zoorob; D Fortin; G Orth
Journal:  Int J Cancer       Date:  1981-05-15       Impact factor: 7.396

7.  Analysis of human genital warts (condylomata acuminata) and other genital tumors for human papillomavirus type 6 DNA.

Authors:  L Gissmann; E M deVilliers; H zur Hausen
Journal:  Int J Cancer       Date:  1982-02-15       Impact factor: 7.396

8.  Variable-sized free episomes of Shope papilloma virus DNA are present in all non-virus-producing neoplasms and integrated episomes are detected in some.

Authors:  F O Wettstein; J G Stevens
Journal:  Proc Natl Acad Sci U S A       Date:  1982-02       Impact factor: 11.205

9.  Nucleotide sequence of the rightward operator of phage lambda.

Authors:  T Maniatis; A Jeffrey; D G Kleid
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205

10.  A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer.

Authors:  M Boshart; L Gissmann; H Ikenberg; A Kleinheinz; W Scheurlen; H zur Hausen
Journal:  EMBO J       Date:  1984-05       Impact factor: 11.598
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  38 in total

1.  In situ hybridization for human papillomavirus as a method of predicting the evolution of cervical intraepithelial neoplasia.

Authors:  A Pich; E Margaria; B Ghiringhello; R Navone
Journal:  Arch Gynecol Obstet       Date:  1992       Impact factor: 2.344

Review 2.  Molecular techniques in the diagnosis of human infectious diseases.

Authors:  U Desselberger; K Collingham
Journal:  Genitourin Med       Date:  1990-10

3.  Progression of the phenotype of transformed cells after growth stimulation of cells by a human papillomavirus type 16 gene function.

Authors:  T Noda; H Yajima; Y Ito
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

4.  Accumulation of RNA homologous to human papillomavirus type 16 open reading frames in genital precancers.

Authors:  C P Crum; G Nuovo; D Friedman; S J Silverstein
Journal:  J Virol       Date:  1988-01       Impact factor: 5.103

5.  Biologic properties and nucleotide sequence analysis of human papillomavirus type 51.

Authors:  O Lungu; C P Crum; S Silverstein
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

6.  Characterization of in vivo expression of the human papillomavirus type 16 E4 protein in cervical biopsy tissues.

Authors:  J M Palefsky; B Winkler; J P Rabanus; C Clark; S Chan; V Nizet; G K Schoolnik
Journal:  J Clin Invest       Date:  1991-06       Impact factor: 14.808

7.  In situ human papillomavirus (HPV) genotyping of cervical intraepithelial neoplasia in South African and British patients: evidence for putative HPV integration in vivo.

Authors:  K Cooper; C S Herrington; A K Graham; M F Evans; J O McGee
Journal:  J Clin Pathol       Date:  1991-05       Impact factor: 3.411

8.  Coinfection of human foreskin fragments with multiple human papillomavirus types (HPV-11, -40, and -LVX82/MM7) produces regionally separate HPV infections within the same athymic mouse xenograft.

Authors:  N D Christensen; W A Koltun; N M Cladel; L R Budgeon; C A Reed; J W Kreider; P A Welsh; S D Patrick; H Yang
Journal:  J Virol       Date:  1997-10       Impact factor: 5.103

9.  Pathology: human papillomavirus infection and cervical neoplasia.

Authors:  B Winkler; J Palefsky
Journal:  West J Med       Date:  1986-09

10.  Occurrence of multiple types of human papillomavirus in genital tract lesions. Analysis by in situ hybridization and the polymerase chain reaction.

Authors:  G J Nuovo; M M Darfler; C C Impraim; S E Bromley
Journal:  Am J Pathol       Date:  1991-01       Impact factor: 4.307
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