Brian I Carr1, Gianluigi Giannelli2, Vito Guerra2, Edoardo G Giannini3, Fabio Farinati4, Gian Ludovico Rapaccini5, Maria Di Marco6, Marco Zoli7, Eugenio Caturelli8, Alberto Masotto9, Roberto Virdone10, Rodolfo Sacco11, Franco Trevisani12. 1. 1 Izmir Biomedicine and Genome Institute (iBG), Dokuz Eylul University, Izmir, Turkey. 2. 2 National Institute of Digestive Diseases, IRCCS Saverio de Bellis, Castellana Grotte, Italy. 3. 3 Department of Internal Medicine, Gastroenterology Unit, University of Genoa, Italy. 4. 4 Department of Surgical Science and Gastroenterology, Gastroenterology Unit, University of Padua, Italy. 5. 5 Internal Medicine and Gastroenterology Unit, Catholic University of Rome, Italy. 6. 6 Division of Medicine, Azienda Ospedaliera Bolognini, Seriate, Italy. 7. 7 Department of Medical and Surgical Science, Internal Medicine Unit, Alma Mater Studiorum, University of Bologna, Italy. 8. 8 Gastroenterology Unit, Ospedale Belcolle, Viterbo, Italy. 9. 9 Gastroenterology Unit, Ospedale Sacro Cuore Don Calabria, Negrar, Italy. 10. 10 Division of Internal Medicine 2, Ospedali Riuniti Villa Sofia Cervello, Palermo, Italy. 11. 11 Unita Operativa Medicina interna 2, Ospedali Riuniti, Cervello, Palermo, Italy and Metabolic Diseases, Pisa University Hospital, Pisa, Italy. 12. 12 Department of Medical Surgical Sciences, Medical Semiotics Unit, Alma Mater Studiorum, University of Bologna, Italy.
Abstract
BACKGROUND AND AIMS:: Hepatocellular carcinoma is associated with several chronic liver diseases, especially chronic hepatitis B virus, hepatitis C virus, and alcoholism. It is increasingly appreciated that obesity/metabolic syndrome is also associated with chronic liver disease and subsequent hepatocellular carcinoma. METHODS: : We retrospectively investigated the serum lipid profiles in a large hepatocellular carcinoma cohort, associated predominantly with the hepatitis B virus, hepatitis C virus, alcohol or nonalcoholic steatohepatitis. The cohort was examined both as a whole, as well as stratified by etiology. RESULTS: : We found significant associations between parameters of hepatocellular carcinoma biology such as maximum tumor diameter, portal vein thrombosis, tumor multifocality or alpha-fetoprotein levels and individual lipid components, including total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides and body mass index. In a final multiple linear regression model considering all lipid variables together, only high-density lipoprotein cholesterol was significantly associated with the tumor Tumor Aggressiveness Index. High-density lipoprotein cholesterol was found to have a statistically higher hazard ratio for death than low high-density lipoprotein cholesterol levels (Cox). On examination by etiological group, alpha-fetoprotein levels were significantly higher in patients with hepatitis C virus compared to those with alcohol or nonalcoholic steatohepatitis, but maximum tumor diameter, tumor multifocality and portal vein thrombosis were similar across etiological groups. Nonalcoholic steatohepatitis patients had significantly less cirrhosis than other groups and hepatitis B virus patients had significantly higher cholesterol and low-density lipoprotein cholesterol levels than hepatitis C virus patients. CONCLUSIONS: : This is the first report, to our knowledge, of a relationship between serum lipid parameters and indices of hepatocellular carcinoma growth, invasion and aggressiveness, as well as with survival.
BACKGROUND AND AIMS:: Hepatocellular carcinoma is associated with several chronic liver diseases, especially chronic hepatitis B virus, hepatitis C virus, and alcoholism. It is increasingly appreciated that obesity/metabolic syndrome is also associated with chronic liver disease and subsequent hepatocellular carcinoma. METHODS: : We retrospectively investigated the serum lipid profiles in a large hepatocellular carcinoma cohort, associated predominantly with the hepatitis B virus, hepatitis C virus, alcohol or nonalcoholic steatohepatitis. The cohort was examined both as a whole, as well as stratified by etiology. RESULTS: : We found significant associations between parameters of hepatocellular carcinoma biology such as maximum tumor diameter, portal vein thrombosis, tumor multifocality or alpha-fetoprotein levels and individual lipid components, including total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides and body mass index. In a final multiple linear regression model considering all lipid variables together, only high-density lipoprotein cholesterol was significantly associated with the tumor Tumor Aggressiveness Index. High-density lipoprotein cholesterol was found to have a statistically higher hazard ratio for death than low high-density lipoprotein cholesterol levels (Cox). On examination by etiological group, alpha-fetoprotein levels were significantly higher in patients with hepatitis C virus compared to those with alcohol or nonalcoholic steatohepatitis, but maximum tumor diameter, tumor multifocality and portal vein thrombosis were similar across etiological groups. Nonalcoholic steatohepatitispatients had significantly less cirrhosis than other groups and hepatitis B viruspatients had significantly higher cholesterol and low-density lipoprotein cholesterol levels than hepatitis C viruspatients. CONCLUSIONS: : This is the first report, to our knowledge, of a relationship between serum lipid parameters and indices of hepatocellular carcinoma growth, invasion and aggressiveness, as well as with survival.
Authors: Sukumar Uday Kumar; Arsenii V Telichko; Huaijun Wang; Dongwoon Hyun; Eric G Johnson; Michael S Kent; Robert B Rebhun; Jeremy J Dahl; William T N Culp; Ramasamy Paulmurugan Journal: Adv Ther (Weinh) Date: 2020-11-12
Authors: H Akkiz; B I Carr; V Guerra; R Donghia; K Yalçın; U Karaoğullarından; E Altıntaş; A Özakyol; H Şimşek; H Y Balaban; A Balkan; A Uyanıkoğlu; N Ekin; A Delik Journal: J Transl Sci Date: 2020-09-16
Authors: Laura Conde de la Rosa; Carmen Garcia-Ruiz; Carmen Vallejo; Anna Baulies; Susana Nuñez; Maria J Monte; Jose J G Marin; Lucia Baila-Rueda; Ana Cenarro; Fernando Civeira; Josep Fuster; Juan C Garcia-Valdecasas; Joana Ferrer; Michael Karin; Vicent Ribas; Jose C Fernandez-Checa Journal: J Hepatol Date: 2021-01-27 Impact factor: 30.083
Authors: Fausto Petrelli; Alessio Cortellini; Alice Indini; Gianluca Tomasello; Michele Ghidini; Olga Nigro; Massimiliano Salati; Lorenzo Dottorini; Alessandro Iaculli; Antonio Varricchio; Valentina Rampulla; Sandro Barni; Mary Cabiddu; Antonio Bossi; Antonio Ghidini; Alberto Zaniboni Journal: JAMA Netw Open Date: 2021-03-01