Literature DB >> 29874052

Restoring Vision to the Blind with Chemical Photoswitches.

Ivan Tochitsky1,2, Michael A Kienzler3, Ehud Isacoff4,5,6, Richard H Kramer4,5.   

Abstract

Degenerative retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration (AMD) affect millions of people around the world and lead to irreversible vision loss if left untreated. A number of therapeutic strategies have been developed over the years to treat these diseases or restore vision to already blind patients. In this Review, we describe the development and translational application of light-sensitive chemical photoswitches to restore visual function to the blind retina and compare the translational potential of photoswitches with other vision-restoring therapies. This therapeutic strategy is enabled by an efficient fusion of chemical synthesis, chemical biology, and molecular biology and is broadly applicable to other biological systems. We hope this Review will be of interest to chemists as well as neuroscientists and clinicians.

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Year:  2018        PMID： 29874052      PMCID： PMC6389275          DOI： 10.1021/acs.chemrev.7b00723

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


  150 in total

1.  Reversibly caged glutamate: a photochromic agonist of ionotropic glutamate receptors.

Authors:  Matthew Volgraf; Pau Gorostiza; Stephanie Szobota; Max R Helix; Ehud Y Isacoff; Dirk Trauner
Journal:  J Am Chem Soc       Date:  2007-01-17       Impact factor: 15.419

2.  Remote control of neuronal activity with a light-gated glutamate receptor.

Authors:  Stephanie Szobota; Pau Gorostiza; Filippo Del Bene; Claire Wyart; Doris L Fortin; Kathleen D Kolstad; Orapim Tulyathan; Matthew Volgraf; Rika Numano; Holly L Aaron; Ethan K Scott; Richard H Kramer; John Flannery; Herwig Baier; Dirk Trauner; Ehud Y Isacoff
Journal:  Neuron       Date:  2007-05-24       Impact factor: 17.173

Review 3.  Azobenzene photoswitches for biomolecules.

Authors:  Andrew A Beharry; G Andrew Woolley
Journal:  Chem Soc Rev       Date:  2011-04-12       Impact factor: 54.564

4.  Spectral transmission of the human crystalline lens in adult and elderly persons: color and total transmission of visible light.

Authors:  Jose M Artigas; Adelina Felipe; Amparo Navea; Adriana Fandiño; Cristina Artigas
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-06-26       Impact factor: 4.799

5.  Block of gap junctions eliminates aberrant activity and restores light responses during retinal degeneration.

Authors:  Abduqodir H Toychiev; Elena Ivanova; Christopher W Yee; Botir T Sagdullaev
Journal:  J Neurosci       Date:  2013-08-28       Impact factor: 6.167

Review 6.  The neuronal organization of the retina.

Authors:  Richard H Masland
Journal:  Neuron       Date:  2012-10-17       Impact factor: 17.173

Review 7.  Taking Stock of Retinal Gene Therapy: Looking Back and Moving Forward.

Authors:  Jean Bennett
Journal:  Mol Ther       Date:  2017-04-05       Impact factor: 12.910

8.  Dynamic increase in extracellular ATP accelerates photoreceptor cell apoptosis via ligation of P2RX7 in subretinal hemorrhage.

Authors:  Shoji Notomi; Toshio Hisatomi; Yusuke Murakami; Hiroto Terasaki; Shozo Sonoda; Ryo Asato; Atsunobu Takeda; Yasuhiro Ikeda; Hiroshi Enaida; Taiji Sakamoto; Tatsuro Ishibashi
Journal:  PLoS One       Date:  2013-01-08       Impact factor: 3.240

Review 9.  Molecular mechanism of acrylamide neurotoxicity: lessons learned from organic chemistry.

Authors:  Richard M LoPachin; Terrence Gavin
Journal:  Environ Health Perspect       Date:  2012-10-11       Impact factor: 9.031

10.  Rates and equilibria for a photoisomerizable antagonist at the acetylcholine receptor of Electrophorus electroplaques.

Authors:  M E Krouse; H A Lester; N H Wassermann; B F Erlanger
Journal:  J Gen Physiol       Date:  1985-08       Impact factor: 4.086
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  27 in total

1.  Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.

Authors:  Christopher A Procyk; Annette E Allen; Franck P Martial; Robert J Lucas
Journal:  J Neurophysiol       Date:  2019-08-28       Impact factor: 2.714

2.  Synthesis of Functionalized Azobiphenyl- and Azoterphenyl- Ditopic Linkers: Modular Building Blocks for Photoresponsive Smart Materials.

Authors:  Sylvain Grosjean; Patrick Hodapp; Zahid Hassan; Christof Wöll; Martin Nieger; Stefan Bräse
Journal:  ChemistryOpen       Date:  2019-06-21       Impact factor: 2.911

3.  Bioresorbable thin-film silicon diodes for the optoelectronic excitation and inhibition of neural activities.

Authors:  Yunxiang Huang; Yuting Cui; Hanjie Deng; Jingjing Wang; Rongqi Hong; Shuhan Hu; Hanqing Hou; Yuanrui Dong; Huachun Wang; Junyu Chen; Lizhu Li; Yang Xie; Pengcheng Sun; Xin Fu; Lan Yin; Wei Xiong; Song-Hai Shi; Minmin Luo; Shirong Wang; Xiaojian Li; Xing Sheng
Journal:  Nat Biomed Eng       Date:  2022-09-05       Impact factor: 29.234

4.  Holographic two-photon activation for synthetic optogenetics.

Authors:  Ido Carmi; Marco De Battista; Laura Maddalena; Elizabeth C Carroll; Michael A Kienzler; Shai Berlin
Journal:  Nat Protoc       Date:  2019-02-25       Impact factor: 13.491

Review 5.  Optical control of neuronal ion channels and receptors.

Authors:  Pierre Paoletti; Graham C R Ellis-Davies; Alexandre Mourot
Journal:  Nat Rev Neurosci       Date:  2019-09       Impact factor: 34.870

6.  Imaging Voltage in Complete Neuronal Networks Within Patterned Microislands Reveals Preferential Wiring of Excitatory Hippocampal Neurons.

Authors:  Alison S Walker; Benjamin K Raliski; Dat Vinh Nguyen; Patrick Zhang; Kate Sanders; Kaveh Karbasi; Evan W Miller
Journal:  Front Neurosci       Date:  2021-05-13       Impact factor: 5.152

7.  A Modular Approach to Arylazo-1,2,3-triazole Photoswitches.

Authors:  Jeremy R Tuck; Robert J Tombari; Noah Yardeny; David E Olson
Journal:  Org Lett       Date:  2021-05-21       Impact factor: 6.072

8.  Retinoic Acid Induces Hyperactivity, and Blocking Its Receptor Unmasks Light Responses and Augments Vision in Retinal Degeneration.

Authors:  Michael Telias; Bristol Denlinger; Zachary Helft; Casey Thornton; Billie Beckwith-Cohen; Richard H Kramer
Journal:  Neuron       Date:  2019-03-12       Impact factor: 18.688

9.  Origins of Ca2+ Imaging with Fluorescent Indicators.

Authors:  Xinqi Zhou; Kayla J Belavek; Evan W Miller
Journal:  Biochemistry       Date:  2021-07-12       Impact factor: 3.162

10.  Trace mild acid-catalysed Z → E isomerization of norbornene-fused stilbene derivatives: intelligent chiral molecular photoswitches with controllable self-recovery.

Authors:  Taotao Hao; Yongsheng Yang; Wenting Liang; Chunying Fan; Xin Wang; Wanhua Wu; Xiaochuan Chen; Haiyan Fu; Hua Chen; Cheng Yang
Journal:  Chem Sci       Date:  2020-12-28       Impact factor: 9.825
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