Literature DB >> 29873673

Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients.

Juliana M DE Souza1, Renan Galaverna2, Aline A N DE Souza1, Timothy J Brocksom1, Julio C Pastre2, Rodrigo O M A DE Souza3, Kleber T DE Oliveira1.   

Abstract

We present a comprehensive review of the advent and impact of continuous flow chemistry with regard to the synthesis of natural products and drugs, important pharmaceutical products and definitely responsible for a revolution in modern healthcare. We detail the beginnings of modern drugs and the large scale batch mode of production, both chemical and microbiological. The introduction of modern continuous flow chemistry is then presented, both as a technological tool for enabling organic chemistry, and as a fundamental research endeavor. This part details the syntheses of bioactive natural products and commercial drugs.

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Year:  2018        PMID： 29873673     DOI： 10.1590/0001-3765201820170778

Source DB:  PubMed          Journal:  An Acad Bras Cienc        ISSN： 0001-3765            Impact factor:   1.753


  8 in total

1.  Scaled up and telescoped synthesis of propofol under continuous-flow conditions.

Authors:  Guilherme M Martins; Maria F A Magalhães; Timothy J Brocksom; Vanderlei S Bagnato; Kleber T de Oliveira
Journal:  J Flow Chem       Date:  2022-07-19       Impact factor: 3.264

Review 2.  3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries.

Authors:  Cloudius R Sagandira; Margaret Siyawamwaya; Paul Watts
Journal:  Arab J Chem       Date:  2020-09-23       Impact factor: 5.165

3.  A Mild, Fast, and Scalable Synthesis of Substituted α-Acyloxy Ketones via Multicomponent Reaction Using a Continuous Flow Approach.

Authors:  Carlos Eduardo M Salvador; Carlos Kleber Z Andrade
Journal:  Front Chem       Date:  2019-07-30       Impact factor: 5.221

4.  Continuous Flow Generation of Acylketene Intermediates via Nitrogen Extrusion.

Authors:  Harry R Smallman; Guilherme A Brancaglion; Julio C Pastre; Duncan L Browne
Journal:  J Org Chem       Date:  2022-09-01       Impact factor: 4.198

5.  Halide-Free Continuous Synthesis of Hydrophobic Ionic Liquids.

Authors:  Kristof Stagel; Andrea Szpecht; Dawid Zielinski; Marcin Smiglak; Michael Schnürch; Katharina Bica-Schröder
Journal:  ACS Sustain Chem Eng       Date:  2022-08-16       Impact factor: 9.224

6.  Reimagining drug manufacturing paradigm in today's pharmacy landscape.

Authors:  Jessica A Miller; Mary E Fredrickson; Jessica M Greene; Michael Jay; Moses O Oyewumi
Journal:  J Am Pharm Assoc (2003)       Date:  2022-08-30

Review 7.  The green chemistry of chalcones: Valuable sources of privileged core structures for drug discovery.

Authors:  Ludovica Marotta; Sara Rossi; Roberta Ibba; Simone Brogi; Vincenzo Calderone; Stefania Butini; Giuseppe Campiani; Sandra Gemma
Journal:  Front Chem       Date:  2022-09-12       Impact factor: 5.545

Review 8.  The evolution of Tamiflu synthesis, 20 years on: Advent of enabling technologies the last piece of the puzzle?

Authors:  Cloudius R Sagandira; Francis M Mathe; Upenyu Guyo; Paul Watts
Journal:  Tetrahedron       Date:  2020-07-26       Impact factor: 2.457
  8 in total

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