| Literature DB >> 29873358 |
Xueze Zhao1, Mingle Li, Wen Sun, Jiangli Fan, Jianjun Du, Xiaojun Peng.
Abstract
In this study, we reported a tamoxifen modified Ru(ii) polypyridyl complex (Ru-tmxf) as an estrogen receptor (ER) targeted photosensitizer. Ru-tmxf displays enhanced cellular uptake and PDT efficiency toward breast cancer cells with high ER expression due to the specific targeting of tamoxifen to ER and finally localizes in lysosomes. Moreover, Ru-tmxf can be activated by two-photon excitation, generating 1O2 to damage lysosomes and result in cell death.Entities:
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Year: 2018 PMID： 29873358 DOI： 10.1039/c8cc03786h
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222