Literature DB >> 29872779

XNA ligation using T4 DNA ligase in crowding conditions.

Donaat Kestemont1, Marleen Renders, Piotr Leonczak, Mikhail Abramov, Guy Schepers, Vitor B Pinheiro, Jef Rozenski, Piet Herdewijn.   

Abstract

T4 DNA ligase is capable of ligating 2'OMe-RNA duplexes, HNA, LNA and FANA mixed sequences in the presence of 10% w/v PEG8000 and 3 M betaine. The enzymatic joining of oligonucleotides containing multiple consecutive XNA nucleotides at the ligation site has not been reported before.

Entities:  

Year:  2018        PMID： 29872779     DOI： 10.1039/c8cc02414f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  4 in total

1.  Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins.

Authors:  Michiel Vanmeert; Jamoliddin Razzokov; Muhammad Usman Mirza; Stephen D Weeks; Guy Schepers; Annemie Bogaerts; Jef Rozenski; Mathy Froeyen; Piet Herdewijn; Vitor B Pinheiro; Eveline Lescrinier
Journal:  Nucleic Acids Res       Date:  2019-07-26       Impact factor: 16.971

Review 2.  Nucleic Acids and Their Analogues for Biomedical Applications.

Authors:  Fei Wang; Pan Li; Hoi Ching Chu; Pik Kwan Lo
Journal:  Biosensors (Basel)       Date:  2022-02-04

3.  Bacterial Cell Display as a Robust and Versatile Platform for Engineering Low-Affinity Ligands and Enzymes.

Authors:  Eszter Csibra; Marleen Renders; Vitor B Pinheiro
Journal:  Chembiochem       Date:  2020-06-29       Impact factor: 3.164

Review 4.  Modified nucleic acids: replication, evolution, and next-generation therapeutics.

Authors:  Karen Duffy; Sebastian Arangundy-Franklin; Philipp Holliger
Journal:  BMC Biol       Date:  2020-09-02       Impact factor: 7.431
  4 in total

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