Literature DB >> 29872560

eIF2α phosphorylation: A hallmark of immunogenic cell death.

Lucillia Bezu1,2,3,4,5,6, Allan Sauvat2,3,4,5,6, Juliette Humeau1,2,3,4,5,6, Marion Leduc2,3,4,5,6, Oliver Kepp2,3,4,5,6, Guido Kroemer2,3,4,5,6,7,8,9.   

Abstract

Immunogenic cell death (ICD) induced by anticancer chemotherapeutics is usually preceded by premortem stress affecting the endoplasmic reticulum (ER). This ER stress does not reflect a canonical unfolded protein response (UPR) but rather manifests solely at the level of the phosphorylation of eIF2α. eIF2α phosphorylation is hence a quintessential hallmark of ICD that can be detected by immunohistochemistry in tumor samples.

Entities:  

Keywords:  ER stress; anthracyclines; cancer; chemotherapy; unfolded protein response

Year:  2018        PMID： 29872560      PMCID： PMC5980344          DOI： 10.1080/2162402X.2018.1431089

Source DB:  PubMed          Journal:  Oncoimmunology        ISSN： 2162-4011            Impact factor:   8.110


  10 in total

Review 1.  Immunogenic cell death in cancer and infectious disease.

Authors:  Lorenzo Galluzzi; Aitziber Buqué; Oliver Kepp; Laurence Zitvogel; Guido Kroemer
Journal:  Nat Rev Immunol       Date:  2016-10-17       Impact factor: 53.106

2.  Chemotherapy-induced antitumor immunity requires formyl peptide receptor 1.

Authors:  Erika Vacchelli; Yuting Ma; Elisa E Baracco; Antonella Sistigu; David P Enot; Federico Pietrocola; Heng Yang; Sandy Adjemian; Kariman Chaba; Michaela Semeraro; Michele Signore; Adele De Ninno; Valeria Lucarini; Francesca Peschiaroli; Luca Businaro; Annamaria Gerardino; Gwenola Manic; Thomas Ulas; Patrick Günther; Joachim L Schultze; Oliver Kepp; Gautier Stoll; Céline Lefebvre; Claire Mulot; Francesca Castoldi; Sylvie Rusakiewicz; Sylvain Ladoire; Lionel Apetoh; José Manuel Bravo-San Pedro; Monica Lucattelli; Cécile Delarasse; Valérie Boige; Michel Ducreux; Suzette Delaloge; Christophe Borg; Fabrice André; Giovanna Schiavoni; Ilio Vitale; Pierre Laurent-Puig; Fabrizio Mattei; Laurence Zitvogel; Guido Kroemer
Journal:  Science       Date:  2015-10-29       Impact factor: 47.728

3.  Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling.

Authors:  Meng Michelle Xu; Yang Pu; Dali Han; Yaoyao Shi; Xuezhi Cao; Hua Liang; Xiang Chen; Xiao-Dong Li; Liufu Deng; Zhijian J Chen; Ralph R Weichselbaum; Yang-Xin Fu
Journal:  Immunity       Date:  2017-08-08       Impact factor: 31.745

Review 4.  The Unfolded Protein Response and Cell Fate Control.

Authors:  Claudio Hetz; Feroz R Papa
Journal:  Mol Cell       Date:  2017-11-05       Impact factor: 17.970

5.  An immunosurveillance mechanism controls cancer cell ploidy.

Authors:  Laura Senovilla; Ilio Vitale; Isabelle Martins; Maximilien Tailler; Claire Pailleret; Mickaël Michaud; Lorenzo Galluzzi; Sandy Adjemian; Oliver Kepp; Mireia Niso-Santano; Shensi Shen; Guillermo Mariño; Alfredo Criollo; Alice Boilève; Bastien Job; Sylvain Ladoire; François Ghiringhelli; Antonella Sistigu; Takahiro Yamazaki; Santiago Rello-Varona; Clara Locher; Vichnou Poirier-Colame; Monique Talbot; Alexander Valent; Francesco Berardinelli; Antonio Antoccia; Fabiola Ciccosanti; Gian Maria Fimia; Mauro Piacentini; Antonio Fueyo; Nicole L Messina; Ming Li; Christopher J Chan; Verena Sigl; Guillaume Pourcher; Christoph Ruckenstuhl; Didac Carmona-Gutierrez; Vladimir Lazar; Josef M Penninger; Frank Madeo; Carlos López-Otín; Mark J Smyth; Laurence Zitvogel; Maria Castedo; Guido Kroemer
Journal:  Science       Date:  2012-09-28       Impact factor: 47.728

6.  eIF2α phosphorylation is pathognomonic for immunogenic cell death.

Authors:  Lucillia Bezu; Allan Sauvat; Juliette Humeau; Lígia C Gomes-da-Silva; Kristina Iribarren; Sabrina Forveille; Pauline Garcia; Liwei Zhao; Peng Liu; Laurence Zitvogel; Laura Senovilla; Oliver Kepp; Guido Kroemer
Journal:  Cell Death Differ       Date:  2018-01-22       Impact factor: 15.828

7.  Calreticulin exposure by malignant blasts correlates with robust anticancer immunity and improved clinical outcome in AML patients.

Authors:  Jitka Fucikova; Iva Truxova; Michal Hensler; Etienne Becht; Lenka Kasikova; Irena Moserova; Sarka Vosahlikova; Jana Klouckova; Sarah E Church; Isabelle Cremer; Oliver Kepp; Guido Kroemer; Lorenzo Galluzzi; Cyril Salek; Radek Spisek
Journal:  Blood       Date:  2016-11-01       Impact factor: 22.113

8.  STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

Authors:  Liufu Deng; Hua Liang; Meng Xu; Xuanming Yang; Byron Burnette; Ainhoa Arina; Xiao-Dong Li; Helena Mauceri; Michael Beckett; Thomas Darga; Xiaona Huang; Thomas F Gajewski; Zhijian J Chen; Yang-Xin Fu; Ralph R Weichselbaum
Journal:  Immunity       Date:  2014-11-06       Impact factor: 31.745

9.  Calreticulin Expression in Human Non-Small Cell Lung Cancers Correlates with Increased Accumulation of Antitumor Immune Cells and Favorable Prognosis.

Authors:  Jitka Fucikova; Etienne Becht; Kristina Iribarren; Jeremy Goc; Romain Remark; Diane Damotte; Marco Alifano; Priyanka Devi; Jerome Biton; Claire Germain; Audrey Lupo; Wolf Herve Fridman; Marie-Caroline Dieu-Nosjean; Guido Kroemer; Catherine Sautès-Fridman; Isabelle Cremer
Journal:  Cancer Res       Date:  2016-02-03       Impact factor: 12.701

10.  Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death.

Authors:  Theocharis Panaretakis; Oliver Kepp; Ulf Brockmeier; Antoine Tesniere; Ann-Charlotte Bjorklund; Daniel C Chapman; Michael Durchschlag; Nicholas Joza; Gérard Pierron; Peter van Endert; Junying Yuan; Laurence Zitvogel; Frank Madeo; David B Williams; Guido Kroemer
Journal:  EMBO J       Date:  2009-01-22       Impact factor: 11.598
  10 in total
  16 in total

Review 1.  Trial watch: dendritic cell vaccination for cancer immunotherapy.

Authors:  Jenny Sprooten; Jolien Ceusters; An Coosemans; Patrizia Agostinis; Steven De Vleeschouwer; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi; Abhishek D Garg
Journal:  Oncoimmunology       Date:  2019-07-18       Impact factor: 8.110

2.  Anticancer effects of anti-CD47 immunotherapy in vivo.

Authors:  Kristina Iribarren; Aitziber Buque; Laura Mondragon; Wei Xie; Sarah Lévesque; Jonathan Pol; Laurence Zitvogel; Oliver Kepp; Guido Kroemer
Journal:  Oncoimmunology       Date:  2018-12-11       Impact factor: 8.110

Review 3.  Immunogenic cell death (ICD)-inducers in non-small-cell lung carcinoma (NSCLC): current knowledge and future perspective.

Authors:  Alireza Kashefizadeh; Hossein Kazemizadeh
Journal:  Clin Transl Oncol       Date:  2022-09-30       Impact factor: 3.340

Review 4.  Trial watch: Peptide-based vaccines in anticancer therapy.

Authors:  Lucillia Bezu; Oliver Kepp; Giulia Cerrato; Jonathan Pol; Jitka Fucikova; Radek Spisek; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi
Journal:  Oncoimmunology       Date:  2018-09-06       Impact factor: 8.110

5.  A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice.

Authors:  Sarah Lévesque; Julie Le Naour; Federico Pietrocola; Juliette Paillet; Margerie Kremer; Francesca Castoldi; Elisa E Baracco; Yan Wang; Erika Vacchelli; Gautier Stoll; Ariane Jolly; Pierre De La Grange; Laurence Zitvogel; Guido Kroemer; Jonathan G Pol
Journal:  Oncoimmunology       Date:  2019-09-07       Impact factor: 8.110

6.  EPHB4 inhibition activates ER stress to promote immunogenic cell death of prostate cancer cells.

Authors:  Vinay Sagar; Rajita Vatapalli; Barbara Lysy; Sahithi Pamarthy; Jonathan F Anker; Yara Rodriguez; Huiying Han; Kenji Unno; Walter M Stadler; William J Catalona; Maha Hussain; Parkash S Gill; Sarki A Abdulkadir
Journal:  Cell Death Dis       Date:  2019-10-22       Impact factor: 8.469

Review 7.  Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology.

Authors:  Isaure Vanmeerbeek; Jenny Sprooten; Dirk De Ruysscher; Sabine Tejpar; Peter Vandenberghe; Jitka Fucikova; Radek Spisek; Laurence Zitvogel; Guido Kroemer; Lorenzo Galluzzi; Abhishek D Garg
Journal:  Oncoimmunology       Date:  2020-01-09       Impact factor: 8.110

Review 8.  Preclinical and Clinical Evidence of Immune Responses Triggered in Oncologic Photodynamic Therapy: Clinical Recommendations.

Authors:  Irati Beltrán Hernández; Yingxin Yu; Ferry Ossendorp; Mladen Korbelik; Sabrina Oliveira
Journal:  J Clin Med       Date:  2020-01-24       Impact factor: 4.241

9.  Tumor-treating fields (TTFields) induce immunogenic cell death resulting in enhanced antitumor efficacy when combined with anti-PD-1 therapy.

Authors:  Tali Voloshin; Noa Kaynan; Shiri Davidi; Yaara Porat; Anna Shteingauz; Rosa S Schneiderman; Einav Zeevi; Mijal Munster; Roni Blat; Catherine Tempel Brami; Shay Cahal; Aviran Itzhaki; Moshe Giladi; Eilon D Kirson; Uri Weinberg; Adrian Kinzel; Yoram Palti
Journal:  Cancer Immunol Immunother       Date:  2020-03-06       Impact factor: 6.968

Review 10.  Detection of immunogenic cell death and its relevance for cancer therapy.

Authors:  Jitka Fucikova; Oliver Kepp; Lenka Kasikova; Giulia Petroni; Takahiro Yamazaki; Peng Liu; Liwei Zhao; Radek Spisek; Guido Kroemer; Lorenzo Galluzzi
Journal:  Cell Death Dis       Date:  2020-11-26       Impact factor: 8.469
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