Literature DB >> 29872482

Cardiovascular Risk in Patients with Subclinical Hypothyroidism.

L H Duntas1, Luca Chiovato2.   

Abstract

Subclinical hypothyroidism (SCH) has been associated with increased cardiovascular mortality due to adverse effects mainly on lipids and blood pressure (BP). There is evidence that SCH, especially in patients with thyroid-stimulating hormone (TSH) >10mU/l, may increase cardiovascular risk. Some uncertainty exists regarding the association of SCH with BP; however, that the coexistence of SCH with BP and hypercholesterolaemia has a negative cardiovascular impact is beyond doubt. Insulin resistance, by modulating various risk factors including coagulation, may potentially increase cardiovascular risk. Periodic health examinations including screening has been advised in patients >35 years of age, while treatment with thyroxine should be tailored to each patient.

Entities:  

Keywords:  Subclinical hypothyroidism; blood pressure; cardiovascular risk; lipids; metabolic syndrome; thyroid-stimulating hormone

Year:  2014        PMID： 29872482      PMCID： PMC5983087          DOI： 10.17925/EE.2014.10.02.157

Source DB:  PubMed          Journal:  Eur Endocrinol        ISSN： 1758-3772


  57 in total

Review 1.  Thyroid hormone-targeting the heart.

Authors:  I Klein; K Ojamaa
Journal:  Endocrinology       Date:  2001-01       Impact factor: 4.736

2.  Subclinical thyroid dysfunction as a risk factor for cardiovascular disease.

Authors:  John P Walsh; Alexandra P Bremner; Max K Bulsara; Peter O'Leary; Peter J Leedman; Peter Feddema; Valdo Michelangeli
Journal:  Arch Intern Med       Date:  2005-11-28

3.  Subclinical thyroid dysfunction and blood pressure: a community-based study.

Authors:  John P Walsh; Alexandra P Bremner; Max K Bulsara; Peter O'Leary; Peter J Leedman; Peter Feddema; Valdo Michelangeli
Journal:  Clin Endocrinol (Oxf)       Date:  2006-10       Impact factor: 3.478

4.  Emerging cardiovascular risk factors in subclinical hypothyroidism: lack of change after restoration of euthyroidism.

Authors:  A Pérez; J M Cubero; N Sucunza; E Ortega; R Arcelús; J Rodriguez-Espinosa; J Ordoñez-Llanos; F Blanco-Vaca
Journal:  Metabolism       Date:  2004-11       Impact factor: 8.694

5.  Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects.

Authors:  Annemieke Roos; Stephan J L Bakker; Thera P Links; Rijk O B Gans; Bruce H R Wolffenbuttel
Journal:  J Clin Endocrinol Metab       Date:  2006-11-07       Impact factor: 5.958

6.  Relation between lipoprotein subfractions and TSH levels in the cardiovascular risk among women with subclinical hypothyroidism.

Authors:  A Hernández-Mijares; A Jover; L Bellod; C Bañuls; E Solá; S Veses; V M Víctor; M Rocha
Journal:  Clin Endocrinol (Oxf)       Date:  2013-05       Impact factor: 3.478

7.  TSH-controlled L-thyroxine therapy reduces cholesterol levels and clinical symptoms in subclinical hypothyroidism: a double blind, placebo-controlled trial (Basel Thyroid Study).

Authors:  C Meier; J J Staub; C B Roth; M Guglielmetti; M Kunz; A R Miserez; J Drewe; P Huber; R Herzog; B Müller
Journal:  J Clin Endocrinol Metab       Date:  2001-10       Impact factor: 5.958

8.  Subclinical hypothyroidism, arterial stiffness, and myocardial reserve.

Authors:  P J D Owen; C Rajiv; D Vinereanu; T Mathew; A G Fraser; J H Lazarus
Journal:  J Clin Endocrinol Metab       Date:  2006-03-14       Impact factor: 5.958

9.  Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality.

Authors:  Nicolas Ochs; Reto Auer; Douglas C Bauer; David Nanchen; Jacobijn Gussekloo; Jacques Cornuz; Nicolas Rodondi
Journal:  Ann Intern Med       Date:  2008-05-19       Impact factor: 25.391

Review 10.  Cardiovascular risk and subclinical hypothyroidism: focus on lipids and new emerging risk factors. What is the evidence?

Authors:  Leonidas H Duntas; Leonard Wartofsky
Journal:  Thyroid       Date:  2007-11       Impact factor: 6.568
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  2 in total

1.  Effect of levothyroxine on cardiac function in children with subclinical hypothyroidism: A quasi-experimental study.

Authors:  Nasrin Banu Rupani; Morteza Alijanpour; Kazem Babazadeh; Karimollah Hajian-Tilaki; Fatemeh Moadabdoost
Journal:  Caspian J Intern Med       Date:  2019

2.  SUBCLINICAL HYPOTHYROIDISM AS A CONTRIBUTOR TO MACROVASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS.

Authors:  Mariya Marushchak; Iryna Vivsiana; Volodymyr Musiienko; Inna Krynytska; Kateryna Kozak
Journal:  Acta Clin Croat       Date:  2022-02       Impact factor: 0.780
  2 in total

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