[Progress on the relationship between IL-35 and respiratory allergic disease].

Interleukin 35(IL-35), a new IL-12 family cytokine, is consisting of IL-12P35 and Epstein-Barr virus-induced gene 3(EBI3) and is required by regulatory T cells(Tregs) for maximal activity. IL-35 is regarded as a promising new type of anti -inflammatory treatment factor, by the in-vitro and mouse models studies confirmed, although the studies have not been able to elucidate the role of IL-35 in human respiratory allergic disease. This paper describes the IL-35 and respiratory allergic diseases of bronchial asthma, allergic rhinitis and research progress in nasal polyps. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.