Alexander P Keil1, David B Richardson1, Daniel Westreich1, Kyle Steenland2. 1. From the Department of Epidemiology, University of North Carolina, Chapel Hill, NC. 2. Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA.
Abstract
BACKGROUND: Respiratory exposure to silica is associated with the risk of death owing to malignant and nonmalignant disease. 2.3 million US workers are exposed to silica. Occupational exposure limits for silica are derived from a number of lines of evidence, including observational studies. Observational studies may be subject to healthy worker survivor bias, which could result in underestimates of silica's impact on worker mortality and, in turn, bias risk estimates for occupational exposure limits. METHODS: Using data on 65,999 workers pooled across multiple industries, we estimate the impacts of several hypothetical occupational exposure limits on silica exposure on lung cancer and all-cause mortality. We use the parametric g-formula, which can account for healthy worker survivor bias. RESULTS: Assuming we could eliminate occupational exposure, we estimate that there would be 20.7 fewer deaths per 1,000 workers in our pooled study by age 80 (95% confidence interval = 14.5, 26.8), including 3.91 fewer deaths owing to lung cancer (95% CI = 1.53, 6.30). Less restrictive interventions demonstrated smaller but still substantial risk reductions. CONCLUSIONS: Our results suggest that occupational exposure limits for silica can be further strengthened to reduce silica-associated mortality and illustrate how current risk analysis for occupational limits can be improved.
BACKGROUND: Respiratory exposure to silica is associated with the risk of death owing to malignant and nonmalignant disease. 2.3 million US workers are exposed to silica. Occupational exposure limits for silica are derived from a number of lines of evidence, including observational studies. Observational studies may be subject to healthy worker survivor bias, which could result in underestimates of silica's impact on worker mortality and, in turn, bias risk estimates for occupational exposure limits. METHODS: Using data on 65,999 workers pooled across multiple industries, we estimate the impacts of several hypothetical occupational exposure limits on silica exposure on lung cancer and all-cause mortality. We use the parametric g-formula, which can account for healthy worker survivor bias. RESULTS: Assuming we could eliminate occupational exposure, we estimate that there would be 20.7 fewer deaths per 1,000 workers in our pooled study by age 80 (95% confidence interval = 14.5, 26.8), including 3.91 fewer deaths owing to lung cancer (95% CI = 1.53, 6.30). Less restrictive interventions demonstrated smaller but still substantial risk reductions. CONCLUSIONS: Our results suggest that occupational exposure limits for silica can be further strengthened to reduce silica-associated mortality and illustrate how current risk analysis for occupational limits can be improved.
Authors: Daniel Westreich; Stephen R Cole; Jessica G Young; Frank Palella; Phyllis C Tien; Lawrence Kingsley; Stephen J Gange; Miguel A Hernán Journal: Stat Med Date: 2012-04-11 Impact factor: 2.373
Authors: Jean Strelitz; Dale P Sandler; Alexander P Keil; David B Richardson; Gerardo Heiss; Marilie D Gammon; Richard K Kwok; Patricia A Stewart; Mark R Stenzel; Lawrence S Engel Journal: Am J Epidemiol Date: 2019-05-01 Impact factor: 4.897
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