Literature DB >> 2987039

Superoxide generation by either 1-oleoyl-2-acetylglycerol or A23187 in human neutrophils is enhanced by indomethacin.

M M Dale, A Penfield.   

Abstract

Indomethacin at a concentration (10(-4) M) which depressed the effect on O2- generation by fMet-Leu-Phe, markedly enhanced O-2 generation by both 1-oleoyl-2-acetylglycerol and the calcium ionophore, A23187. These results are explicable in terms of the hypothesis that synergism between cytosolic calcium and protein kinase C is involved in signal transduction for the respiratory burst in the human neutrophil.

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Year:  1985        PMID: 2987039     DOI: 10.1016/0014-5793(85)80772-9

Source DB:  PubMed          Journal:  FEBS Lett        ISSN: 0014-5793            Impact factor:   4.124


  3 in total

1.  Comparison of the effects of indomethacin, RHC80267 and R59022 on superoxide production by 1,oleoyl-2,acetyl glycerol and A23187 in human neutrophils.

Authors:  M M Dale; A Penfield
Journal:  Br J Pharmacol       Date:  1987-09       Impact factor: 8.739

2.  Proceedings of the British Pharmacological Society. Leeds, 12th-14th July 1989. Abstracts.

Authors: 
Journal:  Br J Pharmacol       Date:  1989-10       Impact factor: 8.739

3.  The stimulation of IL-2 production by anti-rheumatic drugs.

Authors:  J A Oben; G R Wallace; B M Chain; J C Foreman
Journal:  Immunology       Date:  1989-07       Impact factor: 7.397

  3 in total

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