| Literature DB >> 2987022 |
A Sarrieau, N Boige, M Laburthe.
Abstract
Phospholipase digestion of rat intestinal epithelial cell membranes was performed in order to study the influence of membrane phospholipids on the binding activity of VIP receptors. Phospholipases A2 and C strongly (ED50 congruent to 4 X 10(-2) and 4 X 10(-1) micrograms/ml, respectively) and rapidly reduced 125I-VIP binding to membranes whereas phospholipase D was ineffective. This suggests an important role of both hydrophobic and hydrophilic groups of phospholipids on VIP receptor binding activity.Entities:
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Year: 1985 PMID: 2987022 DOI: 10.1007/bf02007693
Source DB: PubMed Journal: Experientia ISSN: 0014-4754