Literature DB >> 2987001

Neuropeptide Y (NPY): enhancement of blood pressure increase upon alpha-adrenoceptor activation and direct pressor effects in pithed rats.

C Dahlöf, P Dahlöf, J M Lundberg.   

Abstract

The effects of neuropeptide Y (NPY) on blood pressure and heart rate were studied in pithed rats. Systemic infusion of NPY in a dose (230 pmol X kg-1 X min-1) which per se did not affect blood pressure enhanced the pressor response to phenylephrine (50 nmol X kg-1 i.v.) and that to electrical stimulation of the sympathetic outflow. In higher doses, NPY caused a pressor effect per se, which was dose-dependently antagonized by nifedipine but not by adrenoceptor antagonists. In conclusion, NPY enhanced the alpha-adrenoceptor-mediated response and had Ca2+-dependent vasoconstrictor activity in vivo.

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Year:  1985        PMID： 2987001     DOI： 10.1016/0014-2999(85)90433-9

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  19 in total

1.  Sympathetic nerves and the endothelium influence the vasoconstrictor effect of low concentrations of ouabain in pressurized small arteries.

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Review 2.  The role of neuropeptides in cardiovascular regulation.

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3.  Potentiation by neuropeptide Y of vasoconstriction in rat resistance arteries.

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4.  Chemical sympathectomy reveals pre- and postsynaptic effects of neuropeptide Y (NPY) in the cardiovascular system.

Authors:  Y Mabe; R Pérez; K Tatemoto; J P Huidobro-Toro
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5.  Innervation of the mink pineal gland with neuropeptide Y (NPY)-containing nerve fibers. An experimental immunohistochemical study.

Authors:  M Møller; J D Mikkelsen; L Martinet
Journal:  Cell Tissue Res       Date:  1990-09       Impact factor: 5.249

6.  Neuropeptide Y differentiates between exocytotic and nonexocytotic noradrenaline release in guinea-pig heart.

Authors:  M Haass; M Hock; G Richardt; A Schömig
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1989-11       Impact factor: 3.000

7.  Neuropeptide Y (NPY)-like immunoreactivity in peripheral and central nerve fibres of the golden hamster (Mesocricetus auratus) with special respect to pineal gland innervation.

Authors:  H Schröder
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Review 8.  Neuropeptide Y and neurovascular control in skeletal muscle and skin.

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Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2009-07-01       Impact factor: 3.619

9.  Cardiac neuropeptide Y and noradrenaline balance in patients with congestive heart failure.

Authors:  Q P Feng; T Hedner; B Andersson; J M Lundberg; F Waagstein
Journal:  Br Heart J       Date:  1994-03

10.  The actions of the peptides, neuropeptide Y and peptide YY, on the vascular and capsular smooth muscle of the isolated, blood-perfused spleen of the dog.

Authors:  R Corder; P J Lowry; P G Withrington
Journal:  Br J Pharmacol       Date:  1987-04       Impact factor: 8.739
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