Fabiano Barbiero1,2, Tina Zanin3, Federica E Pisa1,4, Anica Casetta1, Valentina Rosolen1, Manuela Giangreco1, Corrado Negro5, Massimo Bovenzi5, Fabio Barbone6,7,8. 1. Dipartimento di Area Medica, University of Udine, Via Colugna 50, 33100, Udine, Italy. 2. Health and Safety at Work Department (SPISAL), Local Health Authority No 12, Region of Veneto, Mestre, Italy. 3. Health and Safety at Work Department, Local Health Authority No 2 (ASS2), Region of Friuli Venezia Giulia, Gorizia, Italy. 4. Institute of Hygiene and Clinical Epidemiology, Azienda Sanitaria Universitaria Integrata, Udine, Italy. 5. Department of Medical Sciences, University of Trieste, Trieste, Italy. 6. Dipartimento di Area Medica, University of Udine, Via Colugna 50, 33100, Udine, Italy. fabio.barbone@uniud.it. 7. Institute of Hygiene and Clinical Epidemiology, Azienda Sanitaria Universitaria Integrata, Udine, Italy. fabio.barbone@uniud.it. 8. Department of Medical Sciences, University of Trieste, Trieste, Italy. fabio.barbone@uniud.it.
Abstract
OBJECTIVES: To compare a local cohort of 2488 men occupationally exposed to asbestos and enrolled in a public health surveillance program with the 1995-2009 cancer incidence of the general population of Friuli Venezia Giulia (FVG) region, Northeast Italy, we conducted a historical cohort study. METHODS: Standardized incidence ratios (SIRs), with 95% confidence interval (95% CI), for specific cancer sites were estimated in the cohort and in subgroups of workers employed in shipbuilding between 1974 and 1994. For internal comparisons, we calculated incidence rate ratios (IRRs) for all cancers, lung cancer and mesothelioma, by level of exposure to asbestos and sector of employment adjusted for smoking habits and age at start of follow-up. RESULTS: Among cohort members the SIR was 8.82 (95% CI 5.95-12.61) for mesothelioma and 1.61 (95% CI 1.26-2.04) for lung cancer. In subgroup analyses, the SIR for lung cancer in subjects hired in shipbuilding between 1974 and 1984 was 2.09 (95% CI 1.32-3.13). In the overall cohort, a borderline increased incidence was also found for stomach cancer (SIR = 1.53 95% CI 0.96-2.31). Internal comparisons within the cohort show that among men with high asbestos exposure level the relative risk was almost threefold for lung cancer (IRR = 2.94 95% CI 1.01-8.57). CONCLUSIONS: This cohort experienced an excess in the incidence of both mesothelioma and lung cancer, showing increasing incidence rates at higher level of asbestos exposure. For lung cancer, the relative incidence was highest among workers hired in shipbuilding between 1974 and 1984.
OBJECTIVES: To compare a local cohort of 2488 men occupationally exposed to asbestos and enrolled in a public health surveillance program with the 1995-2009 cancer incidence of the general population of Friuli Venezia Giulia (FVG) region, Northeast Italy, we conducted a historical cohort study. METHODS: Standardized incidence ratios (SIRs), with 95% confidence interval (95% CI), for specific cancer sites were estimated in the cohort and in subgroups of workers employed in shipbuilding between 1974 and 1994. For internal comparisons, we calculated incidence rate ratios (IRRs) for all cancers, lung cancer and mesothelioma, by level of exposure to asbestos and sector of employment adjusted for smoking habits and age at start of follow-up. RESULTS: Among cohort members the SIR was 8.82 (95% CI 5.95-12.61) for mesothelioma and 1.61 (95% CI 1.26-2.04) for lung cancer. In subgroup analyses, the SIR for lung cancer in subjects hired in shipbuilding between 1974 and 1984 was 2.09 (95% CI 1.32-3.13). In the overall cohort, a borderline increased incidence was also found for stomach cancer (SIR = 1.53 95% CI 0.96-2.31). Internal comparisons within the cohort show that among men with high asbestos exposure level the relative risk was almost threefold for lung cancer (IRR = 2.94 95% CI 1.01-8.57). CONCLUSIONS: This cohort experienced an excess in the incidence of both mesothelioma and lung cancer, showing increasing incidence rates at higher level of asbestos exposure. For lung cancer, the relative incidence was highest among workers hired in shipbuilding between 1974 and 1984.
Entities:
Keywords:
Asbestos; Cancer incidence; Epidemiology; Monfalcone; Shipbuilding
Authors: E Orlowski; H Pohlabeln; F Berrino; W Ahrens; U Bolm-Audorff; K Grossgarten; Y Iwatsubo; K H Jöckel; P Brochard Journal: Int J Epidemiol Date: 1993 Impact factor: 7.196
Authors: Vincent James Cogliano; Robert Baan; Kurt Straif; Yann Grosse; Béatrice Lauby-Secretan; Fatiha El Ghissassi; Véronique Bouvard; Lamia Benbrahim-Tallaa; Neela Guha; Crystal Freeman; Laurent Galichet; Christopher P Wild Journal: J Natl Cancer Inst Date: 2011-12-12 Impact factor: 13.506