Literature DB >> 29869258

Drug-Loaded Plant-Virus Based Nanoparticles for Cancer Drug Delivery.

Michael A Bruckman1,2, Anna E Czapar3, Nicole F Steinmetz4,5,6,7,8.   

Abstract

Nature has designed nanosized particles, specifically viruses, equipped to deliver cargo to cells. We report the chemical bioconjugation and shape shifting of a hollow, rod-shaped tobacco mosaic virus (TMV) to dense spherical nanoparticles (SNPs). We describe methods to transform TMV rods to spheres, load TMV rods and spheres with the chemotherapeutic drug, doxorubicin (DOX), to deliver modified particles to breast cancer cells, and to determine the IC50 values of the plant virus-based drug delivery system.

Entities:  

Keywords:  Bioconjugation; Breast cancer; Doxorubicin (DOX); Drug delivery; Tobacco mosaic virus (TMV); Viral nanoparticles (VNPs)

Mesh：

Substances：

Year:  2018        PMID： 29869258     DOI： 10.1007/978-1-4939-7808-3_28

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  4 in total

1.  Tobacco Mosaic Viral Nanoparticle Inhibited Osteoclastogenesis Through Inhibiting mTOR/AKT Signaling.

Authors:  Zhongshu Shan; Hongtao Bi; Angxiu Suonan; Yong Gu; Huan Zhou; Kun Xi; Rui Xiong; Hua Chen; Liang Chen
Journal:  Int J Nanomedicine       Date:  2020-09-29

2.  Affinity Sedimentation and Magnetic Separation With Plant-Made Immunosorbent Nanoparticles for Therapeutic Protein Purification.

Authors:  Matthew J McNulty; Anton Schwartz; Jesse Delzio; Kalimuthu Karuppanan; Aaron Jacobson; Olivia Hart; Abhaya Dandekar; Anatoli Giritch; Somen Nandi; Yuri Gleba; Karen A McDonald
Journal:  Front Bioeng Biotechnol       Date:  2022-04-27

Review 3.  Future of cancer immunotherapy using plant virus-based nanoparticles.

Authors:  Erum Shoeb; Kathleen Hefferon
Journal:  Future Sci OA       Date:  2019-07-25

Review 4.  Viruses of protozoan parasites and viral therapy: Is the time now right?

Authors:  Paul Barrow; Jean Claude Dujardin; Nicolas Fasel; Alex D Greenwood; Klaus Osterrieder; George Lomonossoff; Pier Luigi Fiori; Robert Atterbury; Matteo Rossi; Marco Lalle
Journal:  Virol J       Date:  2020-09-29       Impact factor: 4.099
  4 in total

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