Cross-Linked Collagen Gels Using Gold Nanoparticles.

Cross-linking collagen results in the formation of a collagen matrix that is one of the most widely used biomaterials for applications in drug delivery, tissue engineering, molecular scaffolds, and materials for wound dressing. The properties of the collagen matrix depend on the cross-linking strategy employed. Here we describe the preparation and characterization of a nonfibrillar collagen matrix stabilized by cross-linking with tiopronin-protected, 3-4 nm polyvalent gold nanoparticles.