Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Corticosterone modulation of neurotransmitter receptors in rat hippocampus: a quantitative autoradiographic study.

Literature DB >> 2986762

Corticosterone modulation of neurotransmitter receptors in rat hippocampus: a quantitative autoradiographic study.

Abstract

The effect of adrenalectomy (ADX) and corticosterone (CORT) replacement on neurotransmitter receptors was studied in dorsal hippocampus of rat using quantitative autoradiography. ADX for one week causes an increase in [3H]5-HT binding to 5-HT1 receptors which is significant in the CA1 cell field. CORT treatment of ADX rats for 3-5 days results in localized reductions of [3H]5-HT binding including a partial reversal of the increase observed after ADX in CA1. CORT treatment of ADX animals also decreases binding of [3H]QNB to muscarinic receptors in the dorsal hippocampus, with a significant effect in an area designated as subiculum. No influence of CORT was detected on [3H]prazosin binding to alpha 1 adrenergic receptors in dorsal hippocampus. Possible mechanisms for hormone effects on neurotransmitter receptor levels are discussed.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1985 PMID： 2986762 DOI： 10.1016/0006-8993(85)90599-2

Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252

Keyword Cloud
Cited

11 in total

Review 1. The 5-HT receptor--G-protein--effector system complex in depression. I. Effect of glucocorticoids.

Authors: K P Lesch; B Lerer
Journal: J Neural Transm Gen Sect Date: 1991

2. Neurobiology of suicidal behavior. An integration of biological and clinical findings.

Authors: Juan J Carballo; Chibuikem P Akamnonu; Maria A Oquendo
Journal: Arch Suicide Res Date: 2008

3. Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus.

Authors: M Martire; G Pistritto; P Preziosi
Journal: J Neural Transm Date: 1989 Impact factor: 3.575

4. Regulation of corticosteroid receptor gene expression in depression and antidepressant action.

Authors: N Barden
Journal: J Psychiatry Neurosci Date: 1999-01 Impact factor: 6.186

5. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation.

Authors: J F Deakin; I Pennell; A J Upadhyaya; R Lofthouse
Journal: Psychopharmacology (Berl) Date: 1990 Impact factor: 4.530

6. Chronic corticosterone administration modulates nicotine sensitivity and brain nicotinic receptor binding in C3H mice.

Authors: J R Pauly; E U Grün; A C Collins
Journal: Psychopharmacology (Berl) Date: 1990 Impact factor: 4.530

Corticosterone modulation of neurotransmitter receptors in rat hippocampus: a quantitative autoradiographic study.

Review 1. The 5-HT receptor--G-protein--effector system complex in depression. I. Effect of glucocorticoids.

2. Neurobiology of suicidal behavior. An integration of biological and clinical findings.

3. Different regulation of serotonin receptors following adrenal hormone imbalance in the rat hippocampus and hypothalamus.

4. Regulation of corticosteroid receptor gene expression in depression and antidepressant action.

5. A neuroendocrine study of 5HT function in depression: evidence for biological mechanisms of endogenous and psychosocial causation.

6. Chronic corticosterone administration modulates nicotine sensitivity and brain nicotinic receptor binding in C3H mice.

7. Regulation of hippocampal alpha1d adrenergic receptor mRNA by corticosterone in adrenalectomized rats.

Review 8. Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression.

9. Effects of glucocorticoids on 5-HT1A presynaptic function in the mouse.

10. The corticosterone receptive system in the brain of Tupaia belangeri visualized by in vivo autoradiography.