Literature DB >> 29867284

Global dynamics for switching systems and their extensions by linear differential equations.

Zane Huttinga1, Bree Cummins1, Tomáš Gedeon1, Konstantin Mischaikow2.   

Abstract

Switching systems use piecewise constant nonlinearities to model gene regulatory networks. This choice provides advantages in the analysis of behavior and allows the global description of dynamics in terms of Morse graphs associated to nodes of a parameter graph. The parameter graph captures spatial characteristics of a decomposition of parameter space into domains with identical Morse graphs. However, there are many cellular processes that do not exhibit threshold-like behavior and thus are not well described by a switching system. We consider a class of extensions of switching systems formed by a mixture of switching interactions and chains of variables governed by linear differential equations. We show that the parameter graphs associated to the switching system and any of its extensions are identical. For each parameter graph node, there is an order-preserving map from the Morse graph of the switching system to the Morse graph of any of its extensions. We provide counterexamples that show why possible stronger relationships between the Morse graphs are not valid.

Entities:  

Keywords:  Morse graphs; gene regulation; switching systems; transcription/translation model

Year:  2017        PMID: 29867284      PMCID: PMC5984053          DOI: 10.1016/j.physd.2017.11.003

Source DB:  PubMed          Journal:  Physica D        ISSN: 0167-2789            Impact factor:   2.300


  18 in total

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  4 in total

Review 1.  Qualitative Modeling, Analysis and Control of Synthetic Regulatory Circuits.

Authors:  Madalena Chaves; Hidde de Jong
Journal:  Methods Mol Biol       Date:  2021

Review 2.  Multi-parameter exploration of dynamics of regulatory networks.

Authors:  Tomáš Gedeon
Journal:  Biosystems       Date:  2020-02-10       Impact factor: 1.973

3.  State-dependent effective interactions in oscillator networks through coupling functions with dead zones.

Authors:  Peter Ashwin; Christian Bick; Camille Poignard
Journal:  Philos Trans A Math Phys Eng Sci       Date:  2019-10-28       Impact factor: 4.226

4.  Multistability in the epithelial-mesenchymal transition network.

Authors:  Ying Xin; Bree Cummins; Tomáš Gedeon
Journal:  BMC Bioinformatics       Date:  2020-02-24       Impact factor: 3.169

  4 in total

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