Literature DB >> 29866871

Photo-Induced Electron Transfer Real-Time PCR for Detection of Plasmodium falciparum plasmepsin 2 Gene Copy Number.

Samaly Santos Souza1, Mariangela L'Episcopia2, Carlo Severini2, Venkatachalam Udhayakumar3, Naomi W Lucchi1.   

Abstract

Piperaquine is an important partner drug used in artemisinin-based combination therapies (ACTs). An increase in the plasmepsin 2 and 3 gene copy numbers has been associated with decreased susceptibility of Plasmodium falciparum to piperaquine in Cambodia. Here, we developed a photo-induced electron transfer real-time PCR (PET-PCR) assay to quantify the copy number of the P. falciparumplasmepsin 2 gene (PfPM2) that can be used in countries where P. falciparum is endemic to enhance molecular surveillance.
Copyright © 2018 American Society for Microbiology.

Entities:  

Keywords:  PET-PCR; copy number; malaria; piperaquine

Mesh：

Substances：

Year:  2018        PMID： 29866871      PMCID： PMC6105858          DOI： 10.1128/AAC.00317-18

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


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