Raquel P Souza 1 , Patrícia S Bonfim-Mendonça 1 , Gabrielle M Z F Damke 1 , Analine R B de-Assis Carvalho 1 , Bianca A Ratti 1 , Djaceli S O Dembogurski 2 , Vânia R S da-Silva 1 , Sueli O Silva 1 , Denise B Da-Silva 2 , Marcos L Bruschi 3 , Silvya S Maria-Engler 4 , Marcia E L Consolaro 1 Show Affiliations »
Abstract
BACKGROUND: Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer. METHOD: To explore a new therapeutic candidate for cervical cancer, we have evaluated the effects of artepillin C on cellular viability in a comprehensive panel of human cervical cancer-derived cell lines including HeLa (human papillomavirus/HPV 18-positive), SiHa (HPV 16-positive), CaSki (HPV 16- and 18-positive) and C33A (HPV-negative) cells compared to a spontaneously immortalized human epithelial cell line (HaCaT). RESULTS: Our results demonstrated that artepillin C had a selective effect on cellular viability and could induce apoptosis possibly by intrinsic pathway, likely a result of oxidative stress, in all cancer-derived cell lines but not in HaCaT. Additionally, artepillin C was able to inhibit the migration and invasion of cancer cells. CONCLUSION: Thus, artepillin C appears to be a promising new candidate as an anticancer drug for cervical cancer induced by different HPV types. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND: Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid ) is the main bioactive component of Brazilian green propolis, and possesses, among other things, anticancer properties. However, to the best of our knowledge, there are no studies of artepillin C in cervical cancer . METHOD: To explore a new therapeutic candidate for cervical cancer , we have evaluated the effects of artepillin C on cellular viability in a comprehensive panel of human cervical cancer -derived cell lines including HeLa (human papillomavirus /HPV 18-positive), SiHa (HPV 16 -positive), CaSki (HPV 16 - and 18-positive) and C33A (HPV-negative) cells compared to a spontaneously immortalized human epithelial cell line (HaCaT). RESULTS: Our results demonstrated that artepillin C had a selective effect on cellular viability and could induce apoptosis possibly by intrinsic pathway, likely a result of oxidative stress, in all cancer -derived cell lines but not in HaCaT. Additionally, artepillin C was able to inhibit the migration and invasion of cancer cells. CONCLUSION: Thus, artepillin C appears to be a promising new candidate as an anticancer drug for cervical cancer induced by different HPV types. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities: Chemical
Disease
Species
Keywords:
Artepillin C; apoptosis; cell migration and invasion; cervical cancer; oxidative stress; propolis.
Mesh： See more »
Substances： See more »
Year: 2018
PMID： 29866020 DOI： 10.2174/1871520618666180604092930
Source DB: PubMed Journal: Anticancer Agents Med Chem ISSN： 1871-5206 Impact factor: 2.505