Jacek T Niedziela1, Bartosz Hudzik1,2, Bozena Szygula-Jurkiewicz1, Jolanta U Nowak1, Lech Polonski1, Mariusz Gasior1, Piotr Rozentryt1,3. 1. 3rd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Disease, Zabrze, Poland. 2. Department of Nutrition-related Disease Prevention, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland. 3. Department of Social Medicine & Prevention, School of Public Health in Bytom, Medical University of Silesia, Katowice, Poland.
Abstract
AIM: Albumin-to-globulin ratio (AGR) is emerged as a marker of impaired prognosis. We determined the predictive value of AGR in patients with heart failure with reduced ejection fraction (HFrEF). METHODOLOGY: 999 patients with HFrEF were enrolled. Rates of 1-year all-cause mortality were compared between AGR quartiles (Q). Moreover, multivariate survival analysis in Cox's regression model and receiver operating characteristic analyses were performed. RESULTS: 90-day and 1-year mortality was the highest in AGR Q1. AGR was an independent predictor of 90-day and 1-year mortality. Receiver operating characteristic analysis revealed moderate diagnostic value in predicting 90-day (AGR cutoff <1.2) and 1-year (AGR cutoff <1.38) mortality. CONCLUSION: AGR had a good prognostic value and remained an independent predictor of mortality in HFrEF patients.
AIM: Albumin-to-globulin ratio (AGR) is emerged as a marker of impaired prognosis. We determined the predictive value of AGR in patients with heart failure with reduced ejection fraction (HFrEF). METHODOLOGY: 999 patients with HFrEF were enrolled. Rates of 1-year all-cause mortality were compared between AGR quartiles (Q). Moreover, multivariate survival analysis in Cox's regression model and receiver operating characteristic analyses were performed. RESULTS: 90-day and 1-year mortality was the highest in AGR Q1. AGR was an independent predictor of 90-day and 1-year mortality. Receiver operating characteristic analysis revealed moderate diagnostic value in predicting 90-day (AGR cutoff <1.2) and 1-year (AGR cutoff <1.38) mortality. CONCLUSION: AGR had a good prognostic value and remained an independent predictor of mortality in HFrEF patients.