Literature DB >> 2986547

Interaction of Epstein-Barr virus DNA polymerase and 5'-triphosphates of several antiviral nucleoside analogs.

J F Chiou, Y C Cheng.   

Abstract

The 5'-triphosphates of 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methyluracil, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine, 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-methylcytosine, 9-[(2-hydroxyethoxy)methyl]guanine, and 9-(1,3-dihydroxy-2-propoxymethyl)guanine had lower Ki values for Epstein-Barr virus DNA polymerase than has been reported elsewhere for host DNA polymerase. Inhibition of DNA elongation by these analogs ranged from moderate to strong, suggesting that preferential incorporation of these analogs into DNA by virus DNA polymerase may contribute to antiviral selectivity.

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Year:  1985        PMID： 2986547      PMCID： PMC176288          DOI： 10.1128/AAC.27.3.416

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  17 in total

1.  Epstein-Barr virus-associated antibody patterns in carcinoma of the post-nasal space.

Authors:  A de Schryver; S Friberg; G Klein; W Henle; G Henle; G De-Thé; P Clifford; H C Ho
Journal:  Clin Exp Immunol       Date:  1969-11       Impact factor: 4.330

2.  Antibodies to Epstein-Barr virus in Burkitt's lymphoma and control groups.

Authors:  G Henle; W Henle; P Clifford; V Diehl; G W Kafuko; B G Kirya; G Klein; R H Morrow; G M Munube; P Pike; P M Tukei; J L Ziegler
Journal:  J Natl Cancer Inst       Date:  1969-11       Impact factor: 13.506

3.  Nucleoside analogues with clinical potential in antivirus chemotherapy. The effect of several thymidine and 2'-deoxycytidine analogue 5'-triphosphates on purified human (alpha, beta) and herpes simplex virus (types 1, 2) DNA polymerases.

Authors:  J L Ruth; Y C Cheng
Journal:  Mol Pharmacol       Date:  1981-09       Impact factor: 4.436

4.  Identification and characterization of a DNase induced by Epstein-Barr virus.

Authors:  R S Tan; A K Datta; Y C Cheng
Journal:  J Virol       Date:  1982-12       Impact factor: 5.103

5.  Selective inhibition of DNA replication in herpes simplex virus infected cells by 1-(2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine.

Authors:  H S Allaudeen; J Descamps; R K Sehgal; J J Fox
Journal:  J Biol Chem       Date:  1982-10-25       Impact factor: 5.157

6.  Demonstration of a herpes group virus in cultures of peripheral leukocytes from patients with infectious mononucleosis.

Authors:  V Diehl; G Henle; W Henle; G Kohn
Journal:  J Virol       Date:  1968-07       Impact factor: 5.103

7.  Inhibition of purified human and herpes simplex virus-induced DNA polymerases by 9-(2-hydroxyethoxymethyl)guanine triphosphate. Effects on primer-template function.

Authors:  D Derse; Y C Cheng; P A Furman; M H St Clair; G B Elion
Journal:  J Biol Chem       Date:  1981-11-25       Impact factor: 5.157

8.  Interaction of herpes simplex virus-induced DNA polymerase with 9-(1,3-dihydroxy-2-propoxymethyl)guanine triphosphate.

Authors:  K B Frank; J F Chiou; Y C Cheng
Journal:  J Biol Chem       Date:  1984-02-10       Impact factor: 5.157

9.  Unique spectrum of activity of 9-[(1,3-dihydroxy-2-propoxy)methyl]-guanine against herpesviruses in vitro and its mode of action against herpes simplex virus type 1.

Authors:  Y C Cheng; E S Huang; J C Lin; E C Mar; J S Pagano; G E Dutschman; S P Grill
Journal:  Proc Natl Acad Sci U S A       Date:  1983-05       Impact factor: 11.205

10.  Epstein-Barr virus: inhibition of replication by three new drugs.

Authors:  J C Lin; M C Smith; Y C Cheng; J S Pagano
Journal:  Science       Date:  1983-08-05       Impact factor: 47.728
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  4 in total

1.  Tetrameric ring formation of Epstein-Barr virus polymerase processivity factor is crucial for viral replication.

Authors:  Sanae Nakayama; Takayuki Murata; Yoshihiro Yasui; Kazutaka Murayama; Hiroki Isomura; Teru Kanda; Tatsuya Tsurumi
Journal:  J Virol       Date:  2010-10-06       Impact factor: 5.103

2.  Metabolic activation of 9([2-hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine in human lymphoblastoid cell lines infected with Epstein-Barr virus.

Authors:  J C Lin; D J Nelson; C U Lambe; E I Choi
Journal:  J Virol       Date:  1986-11       Impact factor: 5.103

3.  Sequence and mapping analyses of the herpes simplex virus DNA polymerase gene predict a C-terminal substrate binding domain.

Authors:  J S Gibbs; H C Chiou; J D Hall; D W Mount; M J Retondo; S K Weller; D M Coen
Journal:  Proc Natl Acad Sci U S A       Date:  1985-12       Impact factor: 11.205

4.  Activity of penciclovir against Epstein-Barr virus.

Authors:  T H Bacon; M R Boyd
Journal:  Antimicrob Agents Chemother       Date:  1995-07       Impact factor: 5.191
  4 in total

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