Literature DB >> 29865053

Role of Neuroinflammation in the Trajectory of Alzheimer's Disease and in vivo Quantification Using PET.

Paul Edison1, David J Brooks2,3.   

Abstract

Recent evidence suggests that neuroinflammation and immunity play a significant role in Alzheimer's disease and other neurodegenerative diseases. It has also been observed that, independent of the presence of aggregated proteins, neuroinflammation could be present in different neurodegenerative diseases. It has also been suggested that neuroinflammation could occur well ahead of amyloid deposition in AD. Recent genetic studies and other preclinical studies specifically point to a role of neuroinflammation and, in this review, we evaluate the evidence of neuroinflammation in the Alzheimer's disease trajectory and the different imaging modalities by which we could monitor neuroinflammation in vivo in humans.

Entities:  

Keywords:  Alzheimer’s disease; astrocytes; microglia; neurodegeneration; neuroinflammation

Mesh：

Year:  2018        PMID： 29865053     DOI： 10.3233/JAD-179929

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  9 in total

Review 1.  Neuroimmunology of the female brain across the lifespan: Plasticity to psychopathology.

Authors:  R M Barrientos; P J Brunton; K M Lenz; L Pyter; S J Spencer
Journal:  Brain Behav Immun       Date:  2019-03-11       Impact factor: 7.217

Review 2.  Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

Authors:  Fangda Leng; Paul Edison
Journal:  Nat Rev Neurol       Date:  2020-12-14       Impact factor: 42.937

3.  Longitudinal TSPO expression in tau transgenic P301S mice predicts increased tau accumulation and deteriorated spatial learning.

Authors:  Florian Eckenweber; Jose Medina-Luque; Tanja Blume; Christian Sacher; Gloria Biechele; Karin Wind; Maximilian Deussing; Nils Briel; Simon Lindner; Guido Boening; Barbara von Ungern-Sternberg; Marcus Unterrainer; Nathalie L Albert; Andreas Zwergal; Johannes Levin; Peter Bartenstein; Paul Cumming; Axel Rominger; Günter U Höglinger; Jochen Herms; Matthias Brendel
Journal:  J Neuroinflammation       Date:  2020-07-13       Impact factor: 8.322

Review 4.  A Path Toward Precision Medicine for Neuroinflammatory Mechanisms in Alzheimer's Disease.

Authors:  Harald Hampel; Filippo Caraci; A Claudio Cuello; Giuseppe Caruso; Robert Nisticò; Massimo Corbo; Filippo Baldacci; Nicola Toschi; Francesco Garaci; Patrizia A Chiesa; Steven R Verdooner; Leyla Akman-Anderson; Félix Hernández; Jesús Ávila; Enzo Emanuele; Pedro L Valenzuela; Alejandro Lucía; Mark Watling; Bruno P Imbimbo; Andrea Vergallo; Simone Lista
Journal:  Front Immunol       Date:  2020-03-31       Impact factor: 7.561

Review 5.  Fluid Candidate Biomarkers for Alzheimer's Disease: A Precision Medicine Approach.

Authors:  Eleonora Del Prete; Maria Francesca Beatino; Nicole Campese; Linda Giampietri; Gabriele Siciliano; Roberto Ceravolo; Filippo Baldacci
Journal:  J Pers Med       Date:  2020-11-11

6.  Association of Early β-Amyloid Accumulation and Neuroinflammation Measured With [11C]PBR28 in Elderly Individuals Without Dementia.

Authors:  Sini Toppala; Laura L Ekblad; Jouni Tuisku; Semi Helin; Jarkko J Johansson; Hanna Laine; Eliisa Löyttyniemi; Päivi Marjamäki; Kaj Blennow; Henrik Zetterberg; Antti Jula; Matti Viitanen; Juha O Rinne
Journal:  Neurology       Date:  2021-01-29       Impact factor: 9.910

Review 7.  Novel brain PET imaging agents: Strategies for imaging neuroinflammation in Alzheimer's disease and mild cognitive impairment.

Authors:  Jie Huang
Journal:  Front Immunol       Date:  2022-09-23       Impact factor: 8.786

Review 8.  Applications of amyloid, tau, and neuroinflammation PET imaging to Alzheimer's disease and mild cognitive impairment.

Authors:  Avinash Chandra; Polytimi-Eleni Valkimadi; Gennaro Pagano; Oliver Cousins; George Dervenoulas; Marios Politis
Journal:  Hum Brain Mapp       Date:  2019-09-14       Impact factor: 5.038

9.  In vivo neuroinflammation and cerebral small vessel disease in mild cognitive impairment and Alzheimer's disease.

Authors:  Audrey Low; Elijah Mak; Maura Malpetti; Luca Passamonti; Nicolas Nicastro; James D Stefaniak; George Savulich; Leonidas Chouliaras; Li Su; James B Rowe; Hugh S Markus; John T O'Brien
Journal:  J Neurol Neurosurg Psychiatry       Date:  2020-09-11       Impact factor: 10.154
  9 in total

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