| Literature DB >> 29864959 |
Muhammad Abbas1, Alessia Faggian2, Dahiru Nasiru Sintali3, Ghulam Jilany Khan4, Shagufta Naeem5, Meiqi Shi6, Chen Dingding7.
Abstract
Gastric cancer is the fourth most common worldwide cause of cancer-related death. Early gastric cancer has no associated symptoms, for this reason, patients come to the attention of the clinicians only in advanced stages. This paper aims to give a global view on the biomarkers for gastric cancer and the therapy in use. We discuss VEGF family, HER family, E-cadherin, PD-L1, and PD-L2, FGFR, mTOR. Finally, we considered emerging biomarkers as MET, microsatellite instability, and microRNA variations. Furthermore, we have analyzed in depth the chemotherapeutic and adjuvant therapies used in the clinic nowadays, comparing the overall and progression-free survival between them. Identifying and validating diagnostic, prognostic, predictive, and pharmacodynamic biomarkers will be mandatory to the huge impact on patients' outcomes and for improving the efficiency of the drug development process.Entities:
Keywords: Clinical significance; Emerging markers; Gastric cancer; Predictive biomarkers; Response to treatments; Signaling cascades; Treatment
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Year: 2018 PMID： 29864959 DOI： 10.1016/j.biopha.2018.04.178
Source DB: PubMed Journal: Biomed Pharmacother ISSN： 0753-3322 Impact factor: 6.529