Renato Nisihara1,2, Yasmine Gorczevski Pigosso2, Nathalia Prado2, Shirley R R Utiyama1,3, Gisah A De Carvalho4, Thelma L Skare5. 1. Laboratory of Immunopathology, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil. 2. Department of Medicine, Positivo University, Curitiba, Brazil. 3. Department of Clinical Analysis, Federal University of Paraná, Curitiba, Brazil. 4. Endocrinology Service, Clinical Hospital, Federal University of Paraná, Curitiba, Brazil. 5. Evangelic University Hospital of Curitiba, Curitiba, Brazil.
Abstract
BACKGROUND: Patients with autoimmune thyroid diseases (ATD) such as Graves' disease (GD) and Hashimoto thyroiditis (HT) may have non-organ specific autoantibodies such as antinuclear antibodies (ANA) and rheumatoid factor (RF). AIM: To study the prevalence of rheumatic autoantibodies in a group of ATD patients without known rheumatic diseases and to evaluate its association with the patients' epidemiological and treatment profiles. To follow positive non-organ specific autoantibody-positive ATD individuals to investigate whether they will develop a rheumatic disorder. METHODS: A sample of 154 ATD patients (70 HT and 84 GD; mean age 45.3 ± 14.2) had determination of ANA by immunofluorescence, using hep-2 cells as substrate, extractable nuclear antigen profile by ELISA kits and RF by latex agglutination. Epidemiological and treatment profiles were obtained through chart review. These patients were followed for the mean period of 5 years, between 2010 and 2015. RESULTS: Positive ANA was found in 17.5% (27/154) of the patients: anti-Ro/SS-A in 4/154 (2.5%); anti-RNP in 4/154 (2.5%), and anti-La/SS-B in 3/154 (1.9%). None had anti-Sm antibodies. RF was detected in 12/154 (7.7%) of ATD patients and was more common in older individuals (p = 0.007). There was a positive association between the presence of RF and ANA (p = 0.03; OR 3.89; 95% CI 1.1-13.3). None of the patients with positive autoantibodies developed clinical rheumatic diseases during the period of observation. CONCLUSION: We found rheumatic autoantibodies in 17.5% of ATD patients without rheumatic diseases. None of them were associated with the appearance of clinical rheumatic disorder during the period of 5 years.
BACKGROUND:Patients with autoimmune thyroid diseases (ATD) such as Graves' disease (GD) and Hashimoto thyroiditis (HT) may have non-organ specific autoantibodies such as antinuclear antibodies (ANA) and rheumatoid factor (RF). AIM: To study the prevalence of rheumatic autoantibodies in a group of ATDpatients without known rheumatic diseases and to evaluate its association with the patients' epidemiological and treatment profiles. To follow positive non-organ specific autoantibody-positive ATD individuals to investigate whether they will develop a rheumatic disorder. METHODS: A sample of 154 ATDpatients (70 HT and 84 GD; mean age 45.3 ± 14.2) had determination of ANA by immunofluorescence, using hep-2 cells as substrate, extractable nuclear antigen profile by ELISA kits and RF by latex agglutination. Epidemiological and treatment profiles were obtained through chart review. These patients were followed for the mean period of 5 years, between 2010 and 2015. RESULTS: Positive ANA was found in 17.5% (27/154) of the patients: anti-Ro/SS-A in 4/154 (2.5%); anti-RNP in 4/154 (2.5%), and anti-La/SS-B in 3/154 (1.9%). None had anti-Sm antibodies. RF was detected in 12/154 (7.7%) of ATDpatients and was more common in older individuals (p = 0.007). There was a positive association between the presence of RF and ANA (p = 0.03; OR 3.89; 95% CI 1.1-13.3). None of the patients with positive autoantibodies developed clinical rheumatic diseases during the period of observation. CONCLUSION: We found rheumatic autoantibodies in 17.5% of ATDpatients without rheumatic diseases. None of them were associated with the appearance of clinical rheumatic disorder during the period of 5 years.
Authors: Ivica Lazúrová; Karim Benhatchi; Jozef Rovenský; Darina Kozáková; Hedviga Wagnerová; Mária Tajtáková; Yehuda Shoenfeld; Z Macejova Journal: Ann N Y Acad Sci Date: 2009-09 Impact factor: 5.691
Authors: Basant M Elnady; Naglaa M Kamal; Raneyah H M Shaker; Amal F Soliman; Waleed A Hasan; Hamed A Alghamdi; Mohammed M Algethami; Mohamed Bilal Jajah Journal: Medicine (Baltimore) Date: 2016-09 Impact factor: 1.889