Daisuke Shishikura1, Samuel L Sidharta2, Satoshi Honda1, Kohei Takata1, Susan W Kim1, Jordan Andrews1, Natalie Montarello3, Sinny Delacroix4, Timothy Baillie4, Matthew I Worthley5, Peter J Psaltis5, Stephen J Nicholls6. 1. Vascular Research Centre, Heart Health Theme, South Australian Health & Medical Research Institute, Australia. 2. Discipline of Medicine, University of Adelaide, Adelaide, Australia; Cardiovascular Investigation Unit, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia. 3. Cardiovascular Investigation Unit, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia. 4. Discipline of Medicine, University of Adelaide, Adelaide, Australia. 5. Vascular Research Centre, Heart Health Theme, South Australian Health & Medical Research Institute, Australia; Discipline of Medicine, University of Adelaide, Adelaide, Australia; Cardiovascular Investigation Unit, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia. 6. Vascular Research Centre, Heart Health Theme, South Australian Health & Medical Research Institute, Australia; Discipline of Medicine, University of Adelaide, Adelaide, Australia; Cardiovascular Investigation Unit, University of Adelaide, Royal Adelaide Hospital, Adelaide, Australia. Electronic address: stephen.nicholls@sahmri.com.
Abstract
BACKGROUND AND AIMS: Wall shear stress (WSS) has an important role in the natural history of coronary atherosclerosis. The aim of this study is to investigate the relationship between WSS and the lipid content of atherosclerotic plaques as assessed by near-infrared spectroscopy (NIRS). METHODS: We performed serial NIRS and intravascular ultrasound (IVUS) upon Doppler coronary flow guidewire of coronary plaques at baseline and after 12-18 months in 28 patients with <30% angiographic stenosis, who presented with coronary artery disease. Segmental WSS, plaque burden and NIRS-derived lipid rich plaque (LRP) were evaluated at both time-points in 482 consecutive 2-mm coronary segments. RESULTS: Segments with LRP at baseline (n = 106) had a higher average WSS (1.4 ± 0.6 N/m2), compared to those without LRP (n = 376) (1.2 ± 0.6 N/m2, p<0.001). In segments without baseline LRP, WSS was higher in those who subsequently developed new LRP (n = 35) than those who did not (n = 341) (1.4 ± 0.8 vs. 1.1 ± 0.6 N/m2, p=0.002). Conversely, in segments with baseline LRP, WSS was lower in those who had regression of lipid content (n = 41) than those who did not (n = 65) (1.2 ± 0.4 vs. 1.6 ± 0.7 N/m2, p=0.007). Segments with the highest tertile of WSS displayed greater progression of LCBI irrespective of baseline lipid content (p<0.001). Multivariate analysis revealed that baseline WSS (p=0.017), PAV (p<0.001) and LCBI (p<0.001) were all independent predictors of change in LCBI over time. CONCLUSIONS: Coronary segments with high WSS associate with progression of lipid content over time, which may indicate transformation to a more vulnerable phenotype.
BACKGROUND AND AIMS: Wall shear stress (WSS) has an important role in the natural history of coronary atherosclerosis. The aim of this study is to investigate the relationship between WSS and the lipid content of atherosclerotic plaques as assessed by near-infrared spectroscopy (NIRS). METHODS: We performed serial NIRS and intravascular ultrasound (IVUS) upon Doppler coronary flow guidewire of coronary plaques at baseline and after 12-18 months in 28 patients with <30% angiographic stenosis, who presented with coronary artery disease. Segmental WSS, plaque burden and NIRS-derived lipid rich plaque (LRP) were evaluated at both time-points in 482 consecutive 2-mm coronary segments. RESULTS: Segments with LRP at baseline (n = 106) had a higher average WSS (1.4 ± 0.6 N/m2), compared to those without LRP (n = 376) (1.2 ± 0.6 N/m2, p<0.001). In segments without baseline LRP, WSS was higher in those who subsequently developed new LRP (n = 35) than those who did not (n = 341) (1.4 ± 0.8 vs. 1.1 ± 0.6 N/m2, p=0.002). Conversely, in segments with baseline LRP, WSS was lower in those who had regression of lipid content (n = 41) than those who did not (n = 65) (1.2 ± 0.4 vs. 1.6 ± 0.7 N/m2, p=0.007). Segments with the highest tertile of WSS displayed greater progression of LCBI irrespective of baseline lipid content (p<0.001). Multivariate analysis revealed that baseline WSS (p=0.017), PAV (p<0.001) and LCBI (p<0.001) were all independent predictors of change in LCBI over time. CONCLUSIONS: Coronary segments with high WSS associate with progression of lipid content over time, which may indicate transformation to a more vulnerable phenotype.
Authors: A M Moerman; K Dilba; S Korteland; D H J Poot; S Klein; A van der Lugt; E V Rouwet; K van Gaalen; J J Wentzel; A F W van der Steen; F J H Gijsen; K Van der Heiden Journal: PLoS One Date: 2019-06-06 Impact factor: 3.240
Authors: Eline M J Hartman; Giuseppe De Nisco; Frank J H Gijsen; Suze-Anne Korteland; Anton F W van der Steen; Joost Daemen; Jolanda J Wentzel Journal: Sci Rep Date: 2021-11-11 Impact factor: 4.379
Authors: Yakup Kilic; Hannah Safi; Retesh Bajaj; Patrick W Serruys; Pieter Kitslaar; Anantharaman Ramasamy; Vincenzo Tufaro; Yoshinobu Onuma; Anthony Mathur; Ryo Torii; Andreas Baumbach; Christos V Bourantas Journal: Front Cardiovasc Med Date: 2020-03-31
Authors: Ayla Hoogendoorn; Annette M Kok; Eline M J Hartman; Giuseppe de Nisco; Lorena Casadonte; Claudio Chiastra; Adriaan Coenen; Suze-Anne Korteland; Kim Van der Heiden; Frank J H Gijsen; Dirk J Duncker; Antonius F W van der Steen; Jolanda J Wentzel Journal: Cardiovasc Res Date: 2020-05-01 Impact factor: 10.787