Tyler Hyungtaek Rim1, Sang Yeop Lee1, Hyoung Won Bae1, Gong Je Seong1, Sung Soo Kim1,2,3, Chan Yun Kim1. 1. Department of Ophthalmology, Institute of Vision Research, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea. 2. Yonsei Healthcare Big Data Based Knowledge Integration System Research Center, Yonsei University College of Medicine, Seoul, Korea. 3. Institute of Convergence Science, Yonsei University College of Medicine, Seoul, Korea.
Abstract
PURPOSE: To evaluate the risk of open-angle glaucoma among patients with diabetes. METHODS: This retrospective propensity score-matched cohort study included patients with diabetes and a matched comparison group from the Korean National Health Insurance Service National Health Screening Cohort, which includes approximately 500 000 adults aged ≥40 years. Nondiabetes group was matched to diabetes group in a 1:1 ratio using a propensity score based on age, sex, comorbidities, antihypertensive medication use and medical care visits. Each group was followed from January 1, 2004 to either the date of developing open-angle glaucoma or the date of last follow-up in 2013. RESULTS: Incidence of open-angle glaucoma was 20.0/10 000 person-years in diabetes group (n = 58 358) and 17.0/10 000 person-years in nondiabetes group (n = 58 358). Age- and sex- adjusted hazard ratio (HR) was 1.19 (95% confidence interval [CI], 1.09-1.30). In the subgroup analyses, diabetes was associated with an increased risk of open-angle glaucoma in both younger and older age groups (HR = 1.20 for those aged 40-59 years and HR = 1.18 for those aged 60-79 years) and in both sexes (men, HR = 1.13; women, HR = 1.27). CONCLUSION: Patients diagnosed with diabetes were more likely to develop open-angle glaucoma compared with patients without diabetes.
PURPOSE: To evaluate the risk of open-angle glaucoma among patients with diabetes. METHODS: This retrospective propensity score-matched cohort study included patients with diabetes and a matched comparison group from the Korean National Health Insurance Service National Health Screening Cohort, which includes approximately 500 000 adults aged ≥40 years. Nondiabetes group was matched to diabetes group in a 1:1 ratio using a propensity score based on age, sex, comorbidities, antihypertensive medication use and medical care visits. Each group was followed from January 1, 2004 to either the date of developing open-angle glaucoma or the date of last follow-up in 2013. RESULTS: Incidence of open-angle glaucoma was 20.0/10 000 person-years in diabetes group (n = 58 358) and 17.0/10 000 person-years in nondiabetes group (n = 58 358). Age- and sex- adjusted hazard ratio (HR) was 1.19 (95% confidence interval [CI], 1.09-1.30). In the subgroup analyses, diabetes was associated with an increased risk of open-angle glaucoma in both younger and older age groups (HR = 1.20 for those aged 40-59 years and HR = 1.18 for those aged 60-79 years) and in both sexes (men, HR = 1.13; women, HR = 1.27). CONCLUSION:Patients diagnosed with diabetes were more likely to develop open-angle glaucoma compared with patients without diabetes.
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