OBJECTIVE: To describe trends in Thailand's antiretroviral treatment (ART) program performance assessed by HIV drug resistance early warning indicators (EWIs), as recommended by WHO, between 2009 and 2013. MATERIAL AND METHOD: Seven EWIs were monitored, viral load (VL) testing coverage, VL suppression, retention in ART, lost to follow-up (LTFU), antiretrovirals (ARVs) dispensing practices, on-time pill pick-up, and pharmacy stock-outs. Data from ART adult patients in National Health Security Office Scheme were analyzed except for pharmacy stock-outs, which were reported from hospitals. Aggregated averages were calculated for each EWI. Chi-square for trend was applied to measure significant changes. RESULTS: By September 2013, 174,284 adults were receiving ART at 929 hospitals. Over time, improvement in VL testing coverage (53.8% in 2009 to 79.8% in 2013) was observed. VL suppression and on-time pill pick up rates were well above 90%. Rates of retention in ART declined from 84.0 to 82.9%, whereas LTFU rates increased from 8.3 to 9.2% (p<0.001). Prescriptions with inappropriate ARVs decreased from 0.32 to 0.10% (p<0.001). Of reporting hospitals, 96.1%, 96.3%, and 96.2% observed no ARVs stock-out between 2011 and 2013. CONCLUSION: EWI is a useful tool to monitor ART program performance and to identify area where improvement is needed.
OBJECTIVE: To describe trends in Thailand's antiretroviral treatment (ART) program performance assessed by HIV drug resistance early warning indicators (EWIs), as recommended by WHO, between 2009 and 2013. MATERIAL AND METHOD: Seven EWIs were monitored, viral load (VL) testing coverage, VL suppression, retention in ART, lost to follow-up (LTFU), antiretrovirals (ARVs) dispensing practices, on-time pill pick-up, and pharmacy stock-outs. Data from ART adult patients in National Health Security Office Scheme were analyzed except for pharmacy stock-outs, which were reported from hospitals. Aggregated averages were calculated for each EWI. Chi-square for trend was applied to measure significant changes. RESULTS: By September 2013, 174,284 adults were receiving ART at 929 hospitals. Over time, improvement in VL testing coverage (53.8% in 2009 to 79.8% in 2013) was observed. VL suppression and on-time pill pick up rates were well above 90%. Rates of retention in ART declined from 84.0 to 82.9%, whereas LTFU rates increased from 8.3 to 9.2% (p<0.001). Prescriptions with inappropriate ARVs decreased from 0.32 to 0.10% (p<0.001). Of reporting hospitals, 96.1%, 96.3%, and 96.2% observed no ARVs stock-out between 2011 and 2013. CONCLUSION: EWI is a useful tool to monitor ART program performance and to identify area where improvement is needed.
Entities:
Keywords:
Antiretroviral treatment; Drug resistance; Early warning indicator; HIV; Thailand
Authors: M R Jordan; D E Bennett; M A Wainberg; D Havlir; S Hammer; C Yang; L Morris; M Peeters; A M Wensing; N Parkin; J B Nachega; A Phillips; A De Luca; E Geng; A Calmy; E Raizes; P Sandstrom; C P Archibald; J Perriëns; C M McClure; S Y Hong; J H McMahon; N Dedes; D Sutherland; S Bertagnolio Journal: Clin Infect Dis Date: 2012-05 Impact factor: 9.079
Authors: Sanchai Chasombat; Cheewanan Lertpiriyasuwat; Sombat Thanprasertsuk; Laksami Suebsaeng; Ying Ru Lo Journal: Southeast Asian J Trop Med Public Health Date: 2006-07 Impact factor: 0.267
Authors: A Apisarnthanarak; T Jirayasethpong; C Sa-nguansilp; H Thongprapai; C Kittihanukul; A Kamudamas; A Tungsathapornpong; L M Mundy Journal: HIV Med Date: 2008-05 Impact factor: 3.180
Authors: Serge C Billong; Joseph Fokam; Armand S Nkwescheu; Etienne Kembou; Pascal Milenge; Zephirin Tsomo; Grace Ngute Dion; Avelin F Aghokeng; Eitel N Mpoudi; Peter M Ndumbe; Vittorio Colizzi; Jean B Elat Nfetam Journal: PLoS One Date: 2012-05-17 Impact factor: 3.240
Authors: Joseph Fokam; Armanda Nangmo; Carlson Wandum; Desire Takou; Maria Mercedes Santoro; Anne-Esther Njom Nlend; Francis Ndongo Ateba; Paul Koki Ndombo; Nelly Kamgaing; Cedric Kamta; Andre Essiane; Virginie Lambo; Charles Fokunang; Dora Mbanya; Vittorio Colizzi; Carlo-Federico Perno; Alexis Ndjolo Journal: AIDS Res Ther Date: 2020-05-12 Impact factor: 2.250