| Literature DB >> 29860984 |
Mitsuyoshi Nakao1, Saori Fujiwara2, Hirotaka Iwase3.
Abstract
Estrogen receptor (ER) α-positive breast cancers frequently acquire resistance to endocrine therapy. However, recent studies found that a fraction of these tumors overexpress ER, and that estrogen treatment induces apoptosis. We propose a 'cancer navigation' strategy to systematically lead resistant cells to growth arrest and apoptosis.Entities:
Keywords: Breast cancer; ESR1 gene; endocrine resistance; estrogen receptor; estrogen-induced apoptosis
Mesh：
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Year: 2018 PMID： 29860984 DOI： 10.1016/j.trecan.2018.04.005
Source DB: PubMed Journal: Trends Cancer ISSN： 2405-8025