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Literature DB >> 2986015

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.

Abstract

Following the transfer into fertilized mouse eggs of recombinant genes composed of the upstream region of the rat insulin II gene linked to sequences coding for the large-T antigen of simian virus 40, large-T antigen is detected exclusively in the beta-cells of the endocrine pancreas of transgenic mice. The alpha- and delta-cells normally found in the islets of Langerhans are rare and disordered. Well-vascularized beta-cell tumours arise in mice harbouring and inheriting these hybrid oncogenes.

Entities: Disease Gene Species

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Year: 1985 PMID： 2986015 DOI： 10.1038/315115a0

Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962

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Cited

395 in total

1. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.

Authors: K Ohneda; R G Mirmira; J Wang; J D Johnson; M S German
Journal: Mol Cell Biol Date: 2000-02 Impact factor: 4.272

2. Assessment of ribozyme cleavage efficiency using reverse transcriptase real-time PCR.

Authors: D Klein; M Denis; C Ricordi; R L Pastori
Journal: Mol Biotechnol Date: 2000-03 Impact factor: 2.695

Review 3. Sunitinib in pancreatic neuroendocrine tumors.

Authors: Eric Raymond; Pascal Hammel; Chantal Dreyer; Christian Maatescu; Olivia Hentic; Philippe Ruszniewski; Sandrine Faivre
Journal: Target Oncol Date: 2012-06-02 Impact factor: 4.493

4. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.

Authors: Danielle B Ulanet; Dale L Ludwig; C Ronald Kahn; Douglas Hanahan
Journal: Proc Natl Acad Sci U S A Date: 2010-05-10 Impact factor: 11.205

10. Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements.

Authors: J Whelan; D Poon; P A Weil; R Stein
Journal: Mol Cell Biol Date: 1989-08 Impact factor: 4.272

Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.

1. The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.

2. Assessment of ribozyme cleavage efficiency using reverse transcriptase real-time PCR.

Review 3. Sunitinib in pancreatic neuroendocrine tumors.

4. Insulin receptor functionally enhances multistage tumor progression and conveys intrinsic resistance to IGF-1R targeted therapy.

5. The role of the vascular phase in solid tumor growth: a historical review.

6. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis.

7. L-selectin can facilitate metastasis to lymph nodes in a transgenic mouse model of carcinogenesis.

8. Low dose radiation primed iNOS + M1macrophages modulate angiogenic programming of tumor derived endothelium.

9. TNF-alpha is critical for antitumor but not antiviral T cell immunity in mice.

10. Pancreatic beta-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements.