Mengxuan Zuo1, Haorui Shen2, Jingjing Yin2, Wei Wang2, Yan Zhang2, Dao-Bin Zhou2, Wei Zhang3. 1. Department of Hematology, Peking Union Medical College Hospital, Beijing, China; Department of Minimally Invasive Intervention, Sun Yat-Sen University Cancer Center, Guangzhou, China. 2. Department of Hematology, Peking Union Medical College Hospital, Beijing, China. 3. Department of Hematology, Peking Union Medical College Hospital, Beijing, China. Electronic address: ZhangWei3840@pumch.cn.
Abstract
PURPOSE: The aim of study was to explore the PD-1 expression on Treg cells and its association with T-NHL. METHODS: 137 patients newly diagnosed with T-NHL and 115 healthy controls were enrolled. The expression level of PD-1 was measured by flow cytometry at the time of diagnose and 3-8 course of treatment. RESULTS: Median fluorescence intensity (MFI) of PD-1 on Treg cells in T-NHL patients was significantly higher than that in healthy controls (P < 0.001). MFI of PD-1 in medium/high-risk T-NHL patients were higher than that in low-risk patients (P < 0.05). After treatment with Chidamide combined with chemotherapy, MFI of PD-1 significantly decreased (P < 0.05). In patients with high PD-1 expression (percentage>19.6% and MFI > 580), EFS was significantly lower than patients with low PD-1 expression (percentage<19.6% and MFI < 580). CONCLUSIONS: The PD-1expression on peripheral blood Treg cells of T-NHL patients is related to the diagnosis, prognosis and treatment of disease.
PURPOSE: The aim of study was to explore the PD-1 expression on Treg cells and its association with T-NHL. METHODS: 137 patients newly diagnosed with T-NHL and 115 healthy controls were enrolled. The expression level of PD-1 was measured by flow cytometry at the time of diagnose and 3-8 course of treatment. RESULTS: Median fluorescence intensity (MFI) of PD-1 on Treg cells in T-NHL patients was significantly higher than that in healthy controls (P < 0.001). MFI of PD-1 in medium/high-risk T-NHL patients were higher than that in low-risk patients (P < 0.05). After treatment with Chidamide combined with chemotherapy, MFI of PD-1 significantly decreased (P < 0.05). In patients with high PD-1 expression (percentage>19.6% and MFI > 580), EFS was significantly lower than patients with low PD-1 expression (percentage<19.6% and MFI < 580). CONCLUSIONS: The PD-1expression on peripheral blood Treg cells of T-NHL patients is related to the diagnosis, prognosis and treatment of disease.