Matthew A Kirkman1, Jessica C Pickles2, Amy R Fairchild2, Aimee Avery2, Torsten Pietsch3, Thomas S Jacques2, Kristian Aquilina4. 1. Department of Neurosurgery, Great Ormond Street Hospital, London, United Kingdom; Victor Horsley Department of Neurosurgery, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom. 2. Department of Histopathology, Great Ormond Street Hospital, London, United Kingdom; Developmental Biology and Cancer Programme, UCL Great Ormond Street Institute of Child Health, London, United Kingdom. 3. Department of Neuropathology and Brain Tumor Reference Center, University of Bonn Medical Center, Bonn, Germany. 4. Department of Neurosurgery, Great Ormond Street Hospital, London, United Kingdom. Electronic address: kristian.aquilina@gosh.nhs.uk.
Abstract
BACKGROUND: Advances in molecular profiling have facilitated the emergence of newly defined entities of central nervous system (CNS) tumor, including CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR). Relatively little is known about the clinical behavior of these newly characterized tumors. CASE DESCRIPTION: We describe a pediatric male patient with CNS HGNET-BCOR, who developed seeding of the tumor into the site of the surgical wound within months of surgery and who underwent resection of a residual posterior fossa tumor. CONCLUSIONS: This case emphasizes 3 important points. First, CNS HGNET-BCOR can be aggressive tumors that necessitate close clinical and radiologic surveillance. Second, surveillance imaging in such cases should incorporate the surgical incision site into the field of view, and this should be closely scrutinized to ensure the timely detection of wound site seeding. Third, wound site seeding may still occur despite the use of meticulous surgical techniques. Crown
BACKGROUND: Advances in molecular profiling have facilitated the emergence of newly defined entities of central nervous system (CNS) tumor, including CNS high-grade neuroepithelial tumor with BCOR alteration (CNS HGNET-BCOR). Relatively little is known about the clinical behavior of these newly characterized tumors. CASE DESCRIPTION: We describe a pediatric male patient with CNS HGNET-BCOR, who developed seeding of the tumor into the site of the surgical wound within months of surgery and who underwent resection of a residual posterior fossa tumor. CONCLUSIONS: This case emphasizes 3 important points. First, CNS HGNET-BCOR can be aggressive tumors that necessitate close clinical and radiologic surveillance. Second, surveillance imaging in such cases should incorporate the surgical incision site into the field of view, and this should be closely scrutinized to ensure the timely detection of wound site seeding. Third, wound site seeding may still occur despite the use of meticulous surgical techniques. Crown
Authors: L Cardoen; A Tauziède-Espariat; V Dangouloff-Ros; S Moalla; N Nicolas; C-J Roux; Y Bouchoucha; F Bourdeaut; K Beccaria; S Bolle; G Pierron; C Dufour; F Doz; N Boddaert; H J Brisse Journal: AJNR Am J Neuroradiol Date: 2021-12-09 Impact factor: 3.825