| Literature DB >> 29859174 |
Jeffrey H Stern1, Yangzi Tian2, James Funderburgh3, Graziella Pellegrini4, Kang Zhang5, Jeffrey L Goldberg6, Robin R Ali7, Michael Young8, Yubing Xie2, Sally Temple9.
Abstract
Ocular regenerative therapies are on track to revolutionize treatment of numerous blinding disorders, including corneal disease, cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. A variety of transplantable products, delivered as cell suspensions or as preformed 3D structures combining cells and natural or artificial substrates, are in the pipeline. Here we review the status of clinical and preclinical studies for stem cell-based repair, covering key eye tissues from front to back, from cornea to retina, and including bioengineering approaches that advance cell product manufacturing. While recognizing the challenges, we look forward to a deep portfolio of sight-restoring, stem cell-based medicine. VIDEO ABSTRACT.Entities:
Keywords: cornea; eye; lens; limbal; ocular; ophthalmology; optic nerve; photoreceptors; regenerative medicine; retina; retinal ganglion cells; retinal pigment epithelium; stem cells; trabecular meshwork
Mesh：
Year: 2018 PMID： 29859174 PMCID： PMC6492284 DOI： 10.1016/j.stem.2018.05.013
Source DB: PubMed Journal: Cell Stem Cell ISSN： 1875-9777 Impact factor: 24.633