Literature DB >> 29859122

Correction to: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene.

Duarte Mendes Oliveira1, Katia Grillone1, Chiara Mignogna2, Valentina De Falco3, Carmelo Laudanna1, Flavia Biamonte1, Rosa Locane4, Francesco Corcione5, Massimiliano Fabozzi5, Rosario Sacco4, Giuseppe Viglietto6, Donatella Malanga7, Antonia Rizzuto4.   

Abstract

In the publication of this article [1], there is an error in Fig. 7. The minus and plus signals are inverted which impairs understanding of the results described.

Entities:  

Year:  2018        PMID: 29859122      PMCID: PMC5984746          DOI: 10.1186/s13046-018-0776-5

Source DB:  PubMed          Journal:  J Exp Clin Cancer Res        ISSN: 0392-9078


Correction

In the publication of this article [1], there is an error in Fig. 7. The minus and plus signals are inverted which impairs understanding of the results described.
Fig. 7

From: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene. The RET-G533C mutant is inhibited by vandetanib. a. MTT assay was performed in the presence of two different concentrations of vandetanib. HEK293 cells expressing pBabe were used as negative control and HEK293 cells expressing RET-C634R mutant were used as positive control. Values are shown as bar graphs and all results are the average of experiments performed in triplicate. Statistical significance compared with vehicle was evaluated by Two-Way ANOVA (with multiple comparison Dunnet’s test) (n = 3; **p < 0.01; ***p < 0.001). b. Immunoblot analysis of RET/MAPK pathway (with anti-phosphoY1062 RET, anti-RET, anti phospho-Y202T204 ERK1/2, anti-ERK1/2 antibodies) of HEK293 cells transfected with RET-G533C mutant treated with vehicle or vandetanib (500 nM) for 2 h. HEK293 cells transfected with RET-634 mutant were used as control

Figure 7 should instead be read as indicated in this correction. From: Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene. The RET-G533C mutant is inhibited by vandetanib. a. MTT assay was performed in the presence of two different concentrations of vandetanib. HEK293 cells expressing pBabe were used as negative control and HEK293 cells expressing RET-C634R mutant were used as positive control. Values are shown as bar graphs and all results are the average of experiments performed in triplicate. Statistical significance compared with vehicle was evaluated by Two-Way ANOVA (with multiple comparison Dunnet’s test) (n = 3; **p < 0.01; ***p < 0.001). b. Immunoblot analysis of RET/MAPK pathway (with anti-phosphoY1062 RET, anti-RET, anti phospho-Y202T204 ERK1/2, anti-ERK1/2 antibodies) of HEK293 cells transfected with RET-G533C mutant treated with vehicle or vandetanib (500 nM) for 2 h. HEK293 cells transfected with RET-634 mutant were used as control This has now been included in this erratum.
  1 in total

1.  Next-generation sequencing analysis of receptor-type tyrosine kinase genes in surgically resected colon cancer: identification of gain-of-function mutations in the RET proto-oncogene.

Authors:  Duarte Mendes Oliveira; Katia Grillone; Chiara Mignogna; Valentina De Falco; Carmelo Laudanna; Flavia Biamonte; Rosa Locane; Francesco Corcione; Massimiliano Fabozzi; Rosario Sacco; Giuseppe Viglietto; Donatella Malanga; Antonia Rizzuto
Journal:  J Exp Clin Cancer Res       Date:  2018-04-17
  1 in total
  2 in total

1.  Negative Ultraselection of Patients With RAS/BRAF Wild-Type, Microsatellite-Stable Metastatic Colorectal Cancer Receiving Anti-EGFR-Based Therapy.

Authors:  Giovanni Randon; Giulia Maddalena; Marco Maria Germani; Chiara Carlotta Pircher; Paolo Manca; Francesca Bergamo; Mirella Giordano; Caterina Sposetti; Aldo Montagna; Guglielmo Vetere; Luca Zambelli; Cosimo Rasola; Alessandra Boccaccino; Filippo Pagani; Margherita Ambrosini; Marco Massafra; Gabriella Fontanini; Massimo Milione; Matteo Fassan; Chiara Cremolini; Sara Lonardi; Filippo Pietrantonio
Journal:  JCO Precis Oncol       Date:  2022-04

2.  Modular and mechanistic changes across stages of colorectal cancer.

Authors:  Sara Rahiminejad; Mano R Maurya; Kavitha Mukund; Shankar Subramaniam
Journal:  BMC Cancer       Date:  2022-04-21       Impact factor: 4.638

  2 in total

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