Danijela Radojkovic1,2, Milica Pesic3,4, Dragan Dimic3,4, Tatjana Radjenovic Petkovic5, Sasa Radenkovic3,4, Milena Velojic-Golubovic3,4, Vesna Novak3,6, Ivan Ilic3,7, Milan Radojkovic3,8. 1. Medical Faculty, University of Nis, Nis, Serbia. dr.danijela3@gmail.com. 2. Clinic of Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre Nis, Vojislav Ilic bb, 18000, Nis, Serbia. dr.danijela3@gmail.com. 3. Medical Faculty, University of Nis, Nis, Serbia. 4. Clinic of Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre Nis, Vojislav Ilic bb, 18000, Nis, Serbia. 5. Biochemistry Institute, Clinical Centre Nis, Nis, Serbia. 6. Neurosurgery Clinic, Clinical Centre Nis, Nis, Serbia. 7. Pathology Institute, Clinical Centre Nis, Nis, Serbia. 8. Surgery Clinic, Clinical Centre Nis, Nis, Serbia.
Abstract
INTRODUCTION: Langerhans cell histiocytosis (LCH) localised in the hypothalamic-pituitary region (HPR) is very rare, especially in adults. Diabetes insipidus (DI) is considered to be a hallmark of HPR LCH, while anterior pituitary abnormalities are usually seen as consequences of surgery, radiotherapy or chemotherapy. CASE DESCRIPTION: We present a patient with localised HPR LCH with dominant anterior pituitary dysfunction and tumour mass effects but without DI. Seven years after surgery and local radiotherapy, she is stable. Control MRI shows no residual tumour growth and thorough physical examination is still without any signs of disease spread. CONCLUSIONS: Anterior pituitary deficiency can appear without DI and not only as a consequence of LCH treatment. All patients with LCH should be screened for this endocrine abnormality so that appropriate substitution therapy may be provided.
INTRODUCTION: Langerhans cell histiocytosis (LCH) localised in the hypothalamic-pituitary region (HPR) is very rare, especially in adults. Diabetes insipidus (DI) is considered to be a hallmark of HPR LCH, while anterior pituitary abnormalities are usually seen as consequences of surgery, radiotherapy or chemotherapy. CASE DESCRIPTION: We present a patient with localised HPR LCH with dominant anterior pituitary dysfunction and tumour mass effects but without DI. Seven years after surgery and local radiotherapy, she is stable. Control MRI shows no residual tumour growth and thorough physical examination is still without any signs of disease spread. CONCLUSIONS:Anterior pituitary deficiency can appear without DI and not only as a consequence of LCH treatment. All patients with LCH should be screened for this endocrine abnormality so that appropriate substitution therapy may be provided.