E Mengel1,2, V Tillmann3,4, L Remmel5, P Kool4, P Purge5, E Lätt5, J Jürimäe5. 1. Institute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Jakobi 5, 50411, Tartu, Estonia. evamengel0@gmail.com. 2. Children's Clinic of Tartu University Hospital, Tartu, Estonia. evamengel0@gmail.com. 3. Children's Clinic of Tartu University Hospital, Tartu, Estonia. 4. Institute of Clinical Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia. 5. Institute of Sport Sciences and Physiotherapy, Faculty of Medicine, University of Tartu, Jakobi 5, 50411, Tartu, Estonia.
Abstract
Adipose tissue produces different inflammatory cytokines which compromise bone mineral accrual during puberty. Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), interleukin (IL)-8, and interferon-gamma (IFN-γ) are significantly related to bone mineral accrual during pubertal maturation in boys with different BMI values. INTRODUCTION: This longitudinal study aims to identify the inflammatory markers that most strongly associate with pubertal bone mineral density (BMD) increment in boys with overweight and obesity (OWB). METHODS: Twenty-six OWB and 29 normal-weight boys were followed yearly for 3 years to measure changes in 12 serum inflammatory markers, BMD (by DXA), and apparent volumetric BMD. The OWB group was further divided into two subgroups according to their BMI gain during the 3-year period. Data through time points presented as slopes were used to calculate correlation coefficients to explore the possible relationships between variables of interest. In the whole study group, linear mixed effects (LME) models were also used. RESULTS: Increment in serum VEGF concentration was inversely associated with an increase in total body (TB) BMD (r = - 0.82, P = 0.02) and TB bone mineral content (BMC)/height (r = - 0.82, P = 0.02) in those OWB whose BMI gain was higher during pubertal years. In the whole study group, the LME model confirmed the inverse association between VEGF and TB BMC/height (P < 0.05). EGF was inversely associated with LS BMD and LS BMAD (P < 0.05), whereas there was a positive association between IL-8 and TB BMAD and between IFN-γ and LS BMD (P < 0.05). CONCLUSIONS: Lower increment in BMD in OWB with higher BMI gain is associated with increasing serum VEGF concentration during pubertal maturation. VEGF, EGF, IL-8, and IFN-γ are significantly associated with BMD during pubertal maturation in boys with different BMI values.
Adipose tissue produces different inflammatory cytokines which compromise bone mineral accrual during puberty. Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), interleukin (IL)-8, and interferon-gamma (IFN-γ) are significantly related to bone mineral accrual during pubertal maturation in boys with different BMI values. INTRODUCTION: This longitudinal study aims to identify the inflammatory markers that most strongly associate with pubertal bone mineral density (BMD) increment in boys with overweight and obesity (OWB). METHODS: Twenty-six OWB and 29 normal-weight boys were followed yearly for 3 years to measure changes in 12 serum inflammatory markers, BMD (by DXA), and apparent volumetric BMD. The OWB group was further divided into two subgroups according to their BMI gain during the 3-year period. Data through time points presented as slopes were used to calculate correlation coefficients to explore the possible relationships between variables of interest. In the whole study group, linear mixed effects (LME) models were also used. RESULTS: Increment in serum VEGF concentration was inversely associated with an increase in total body (TB) BMD (r = - 0.82, P = 0.02) and TB bone mineral content (BMC)/height (r = - 0.82, P = 0.02) in those OWB whose BMI gain was higher during pubertal years. In the whole study group, the LME model confirmed the inverse association between VEGF and TB BMC/height (P < 0.05). EGF was inversely associated with LS BMD and LS BMAD (P < 0.05), whereas there was a positive association between IL-8 and TB BMAD and between IFN-γ and LS BMD (P < 0.05). CONCLUSIONS: Lower increment in BMD in OWB with higher BMI gain is associated with increasing serum VEGF concentration during pubertal maturation. VEGF, EGF, IL-8, and IFN-γ are significantly associated with BMD during pubertal maturation in boys with different BMI values.
Entities:
Keywords:
Body mass index; Bone mineral density; Boys; Cytokines; Inflammation; Puberty
Authors: L Gracia-Marco; F B Ortega; D Jiménez-Pavón; G Rodríguez; M J Castillo; G Vicente-Rodríguez; L A Moreno Journal: Osteoporos Int Date: 2011-05-12 Impact factor: 4.507
Authors: Eva Mengel; Vallo Tillmann; Liina Remmel; Pille Kool; Priit Purge; Evelin Lätt; Jaak Jürimäe Journal: Calcif Tissue Int Date: 2017-04-03 Impact factor: 4.333
Authors: Charmaine S Tam; Sarah P Garnett; Christopher T Cowell; Leonie K Heilbronn; Jennifer W Lee; Melanie Wong; Louise A Baur Journal: Horm Res Paediatr Date: 2010-02-09 Impact factor: 2.852
Authors: Y Morimoto; S M Conroy; N J Ollberding; Y Kim; U Lim; R V Cooney; A A Franke; L R Wilkens; B Y Hernandez; M T Goodman; B E Henderson; L N Kolonel; L Le Marchand; G Maskarinec Journal: Int J Obes (Lond) Date: 2014-02-13 Impact factor: 5.095
Authors: P Dimitri; R M Jacques; M Paggiosi; D King; J Walsh; Z A Taylor; A F Frangi; N Bishop; R Eastell Journal: J Clin Endocrinol Metab Date: 2014-11-20 Impact factor: 5.958
Authors: Andrea Palermo; Dario Tuccinardi; Giuseppe Defeudis; Mikiko Watanabe; Luca D'Onofrio; Angelo Lauria Pantano; Nicola Napoli; Paolo Pozzilli; Silvia Manfrini Journal: Int J Environ Res Public Health Date: 2016-05-28 Impact factor: 3.390