Komal P Singh1, Kord M Kober1, Anand A Dhruva2, Elena Flowers1, Steve M Paul1, Marilyn J Hammer3, Frances Cartwright3, Fay Wright4, Yvette P Conley5, Jon D Levine2, Christine Miaskowski6. 1. School of Nursing, University of California, San Francisco, California, USA. 2. School of Medicine, University of California, San Francisco, California, USA. 3. Department of Nursing, Mount Sinai Hospital, New York, New York, USA. 4. School of Nursing, New York University, New York, New York, USA. 5. School of Nursing, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. 6. School of Nursing, University of California, San Francisco, California, USA. Electronic address: chris.miaskowski@ucsf.edu.
Abstract
CONTEXT: Despite current advances in antiemetic treatments, between 19% and 58% of oncology patients experience chemotherapy-induced nausea (CIN). OBJECTIVES: Aims of this post hoc exploratory analysis were to determine occurrence, severity, and distress of CIN and evaluate for differences in demographic and clinical characteristics, symptom severity, stress; and quality of life (QOL) outcomes between oncology patients who did and did not report CIN in the week before chemotherapy (CTX). Demographic, clinical, symptom, and stress characteristics associated with CIN occurrence were determined. METHODS: Patients (n = 1296) completed questionnaires that provided information on demographic and clinical characteristics, symptom severity, stress, and QOL. Univariate analyses evaluated for differences in demographic and clinical characteristics, symptom severity, stress, and QOL scores between the two patient groups. Multiple logistic regression analysis was used to evaluate for factors associated with nausea group membership. RESULTS: Of the 1296 patients, 47.5% reported CIN. In the CIN group, 15% rated CIN as severe and 23% reported high distress. Factors associated with CIN included less education; having childcare responsibilities; poorer functional status; higher levels of depression, sleep disturbance, evening fatigue, and intrusive thoughts; as well as receipt of CTX on a 14-day CTX cycle and receipt of an antiemetic regimen that contained serotonin receptor antagonist and steroid. Patients in the CIN group experienced clinically meaningful decrements in QOL. CONCLUSION: This study identified new factors (e.g., poorer functional status, stress) associated with CIN occurrence. CIN negatively impacted patients' QOL. Pre-emptive and ongoing interventions may alleviate CIN occurrence in high-risk patients.
CONTEXT: Despite current advances in antiemetic treatments, between 19% and 58% of oncology patients experience chemotherapy-induced nausea (CIN). OBJECTIVES: Aims of this post hoc exploratory analysis were to determine occurrence, severity, and distress of CIN and evaluate for differences in demographic and clinical characteristics, symptom severity, stress; and quality of life (QOL) outcomes between oncology patients who did and did not report CIN in the week before chemotherapy (CTX). Demographic, clinical, symptom, and stress characteristics associated with CIN occurrence were determined. METHODS:Patients (n = 1296) completed questionnaires that provided information on demographic and clinical characteristics, symptom severity, stress, and QOL. Univariate analyses evaluated for differences in demographic and clinical characteristics, symptom severity, stress, and QOL scores between the two patient groups. Multiple logistic regression analysis was used to evaluate for factors associated with nausea group membership. RESULTS: Of the 1296 patients, 47.5% reported CIN. In the CIN group, 15% rated CIN as severe and 23% reported high distress. Factors associated with CIN included less education; having childcare responsibilities; poorer functional status; higher levels of depression, sleep disturbance, evening fatigue, and intrusive thoughts; as well as receipt of CTX on a 14-day CTX cycle and receipt of an antiemetic regimen that contained serotonin receptor antagonist and steroid. Patients in the CIN group experienced clinically meaningful decrements in QOL. CONCLUSION: This study identified new factors (e.g., poorer functional status, stress) associated with CIN occurrence. CIN negatively impacted patients' QOL. Pre-emptive and ongoing interventions may alleviate CIN occurrence in high-risk patients.
Authors: Komal Singh; Kord M Kober; Steven M Paul; Marilyn Hammer; Fay Wright; Yvette P Conley; Jon D Levine; Christine Miaskowski Journal: Support Care Cancer Date: 2019-08-19 Impact factor: 3.603
Authors: Komal P Singh; Anand Dhruva; Elena Flowers; Steven M Paul; Marilyn J Hammer; Fay Wright; Frances Cartwright; Yvette P Conley; Michelle Melisko; Jon D Levine; Christine Miaskowski; Kord M Kober Journal: J Pain Symptom Manage Date: 2020-01-08 Impact factor: 3.612
Authors: Alissa Nolden; Paule V Joseph; Kord M Kober; Bruce A Cooper; Steven M Paul; Marilyn J Hammer; Laura B Dunn; Yvette P Conley; Jon D Levine; Christine Miaskowski Journal: J Pain Symptom Manage Date: 2019-07-23 Impact factor: 3.612
Authors: Komal Singh; Steven M Paul; Kord M Kober; Yvette P Conley; Fay Wright; Jon D Levine; Paule V Joseph; Christine Miaskowski Journal: J Pain Symptom Manage Date: 2019-11-02 Impact factor: 3.612
Authors: Komal Singh; Keenan Pituch; Qiyun Zhu; Haiwei Gu; Brenda Ernst; Cindy Tofthagen; Melanie Brewer; Kord M Kober; Bruce A Cooper; Steven M Paul; Yvette P Conley; Marilyn Hammer; Jon D Levine; Christine Miaskowski Journal: Cancer Nurs Date: 2022-03-02 Impact factor: 2.760
Authors: Komal Singh; Huangshen Cao; Christine Miaskowski; Yvette P Conley; Marilyn Hammer; Fay Wright; Jon D Levine; Kord M Kober Journal: Biol Res Nurs Date: 2020-08-20 Impact factor: 2.522
Authors: Kord M Kober; Ritu Roy; Anand Dhruva; Yvette P Conley; Raymond J Chan; Bruce Cooper; Adam Olshen; Christine Miaskowski Journal: Fatigue Date: 2021-02-16
Authors: Elise J Devlin; Hayley S Whitford; Anita R Peoples; Gary R Morrow; Sreedhar Katragadda; Jeffrey K Giguere; Bilal Naqvi; Joseph Roscoe Journal: Eur J Cancer Care (Engl) Date: 2021-07-29 Impact factor: 2.328