Angeliki Makri1, Alison M Boyce2, Constantine A Stratakis3, Maya Lodish3. 1. The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland. Electronic address: angeliki.makri@nih.gov. 2. Section on Skeletal Disorders and Mineral Homeostasis, Craniofacial and Skeletal Diseases Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland. 3. The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland.
Abstract
BACKGROUND: The long-term morbidity of childhood cancer survivors is an emerging field as more patients are now expected to live through adulthood. CASE: We describe 2 adolescent patients with permanent premature ovarian failure and failure of endometrium to respond to estrogen after they received a combination of chemotherapy and pelvic radiation for metastatic Ewing sarcoma. Both girls were prepubertal at diagnosis of Ewing sarcoma. Puberty was induced with high-dose estrogen and progesterone; however, none of the patients had withdrawal bleeding. SUMMARY AND CONCLUSION: It is critical to counsel these patients that menstruation might not be possible even with hormone replacement therapy.
BACKGROUND: The long-term morbidity of childhood cancer survivors is an emerging field as more patients are now expected to live through adulthood. CASE: We describe 2 adolescent patients with permanent premature ovarian failure and failure of endometrium to respond to estrogen after they received a combination of chemotherapy and pelvic radiation for metastatic Ewing sarcoma. Both girls were prepubertal at diagnosis of Ewing sarcoma. Puberty was induced with high-dose estrogen and progesterone; however, none of the patients had withdrawal bleeding. SUMMARY AND CONCLUSION: It is critical to counsel these patients that menstruation might not be possible even with hormone replacement therapy.
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