Toni Similä1, Juha Auvinen2, Katri Puukka3, Sirkka Keinänen-Kiukaanniemi4, Jorma I Virtanen5. 1. Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, P.O. Box 5000, Oulu 90014, Finland; Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland. Electronic address: toni.simila@oulu.fi. 2. Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland; Center for Life Course Health Research, University of Oulu, P.O. Box 5000, Oulu 90014, Finland. Electronic address: juha.auvinen@oulu.fi. 3. Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland; NordLab Oulu, Oulu University Hospital, P.O. Box 500, Oulu 90029, Finland. Electronic address: katri.puukka@nordlab.fi. 4. Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland; Center for Life Course Health Research, University of Oulu, P.O. Box 5000, Oulu 90014, Finland; Health Center of Oulu, Oulu, Finland. Electronic address: sirkka.keinanen-kiukaanniemi@oulu.fi. 5. Research Unit of Oral Health Sciences, Faculty of Medicine, University of Oulu, P.O. Box 5000, Oulu 90014, Finland; Medical Research Center Oulu, Oulu University Hospital, P.O. Box 5000, Oulu 90029, Finland. Electronic address: jorma.virtanen@oulu.fi.
Abstract
AIM: We investigated the association of impaired glucose metabolism with tooth loss in adults in the Northern Finland Birth Cohort Study 1966 (NFBC1966). METHODS: We examined 4394 participants from the 46-year follow-up of the NFBC1966. Self-reported number of teeth as well as insulin and glucose values, taken during a standard oral glucose tolerance test (OGTT), served as the primary study variables. A multinomial logistic regression model served to analyse (unadjusted, smoking-adjusted and fully adjusted) the association between number of teeth (0-24, 25-27, 28-32) and glucose metabolism in women and men. RESULTS: Among women, type 2 diabetes - whether previously known or detected during screening - pointed to a higher likelihood of 0-24 teeth (fully adjusted OR = 2.99, 95%CI = 1.54-5.80) and 25-27 teeth (OR = 1.91, 95%CI = 1.18-3.08) than did normal glucose tolerance. Similarly, impaired fasting glucose and impaired glucose tolerance together indicated a higher likelihood of 0-24 teeth (OR = 1.71, 95%CI = 1.09-2.69) than did normal glucose tolerance. A similar, statistically non-significant, pattern emerged among men. Number of teeth associated with OGTT insulin and glucose curves as well as with the Matsuda index in both women and men. CONCLUSIONS: Tooth loss strongly associated with impaired glucose metabolism in middle-aged Finnish women.
AIM: We investigated the association of impaired glucose metabolism with tooth loss in adults in the Northern Finland Birth Cohort Study 1966 (NFBC1966). METHODS: We examined 4394 participants from the 46-year follow-up of the NFBC1966. Self-reported number of teeth as well as insulin and glucose values, taken during a standard oral glucose tolerance test (OGTT), served as the primary study variables. A multinomial logistic regression model served to analyse (unadjusted, smoking-adjusted and fully adjusted) the association between number of teeth (0-24, 25-27, 28-32) and glucose metabolism in women and men. RESULTS: Among women, type 2 diabetes - whether previously known or detected during screening - pointed to a higher likelihood of 0-24 teeth (fully adjusted OR = 2.99, 95%CI = 1.54-5.80) and 25-27 teeth (OR = 1.91, 95%CI = 1.18-3.08) than did normal glucose tolerance. Similarly, impaired fasting glucose and impaired glucose tolerance together indicated a higher likelihood of 0-24 teeth (OR = 1.71, 95%CI = 1.09-2.69) than did normal glucose tolerance. A similar, statistically non-significant, pattern emerged among men. Number of teeth associated with OGTT insulin and glucose curves as well as with the Matsuda index in both women and men. CONCLUSIONS:Tooth loss strongly associated with impaired glucose metabolism in middle-aged Finnish women.
Authors: Shaimaa-Mohamed Fouda; Mohammed M Gad; Maha El Tantawi; Jorma I Virtanen; Kirsi Sipila; Aune Raustia Journal: J Clin Exp Dent Date: 2019-09-01
Authors: Lotte P M Weijdijk; Laura Ziukaite; G A Fridus Van der Weijden; Eric W P Bakker; Dagmar Else Slot Journal: Int J Dent Hyg Date: 2021-08-24 Impact factor: 2.725