| Literature DB >> 29856950 |
Francesco P Marchese1, Maite Huarte2.
Abstract
The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.Entities:
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Year: 2018 PMID： 29856950 DOI： 10.1016/j.cell.2018.05.023
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582