E E Amin1,2,3, M A Joore2, H Ten Cate1,3, K Meijer4, L W Tick5, S Middeldorp6, G J M Mostard7, M Ten Wolde8, S M van den Heiligenberg9, S van Wissen10, M H W van de Poel11, S Villalta12, E H Serné13, H-M Otten14, E H Klappe15, P Prandoni16, A J Ten Cate-Hoek1,3. 1. Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, the Netherlands. 2. Department of Clinical Epidemiology and Medical Technology Assessment, School for Public Health and Primary Care, Maastricht University, Maastricht, the Netherlands. 3. Department of Internal Medicine, Maastricht University Medical Center, Maastricht, the Netherlands. 4. Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. 5. Department of Internal Medicine, Maxima Medical Center Eindhoven, Eindhoven, the Netherlands. 6. Department of Vascular Medicine, Academic Medical Center Amsterdam, Amsterdam, the Netherlands. 7. Department of Internal Medicine, Zuyderland Medical Center, Heerlen, the Netherlands. 8. Department of Internal Medicine, Flevoziekenhuis, Almere, the Netherlands. 9. Department of Internal Medicine, Westfriesgasthuis, Hoorn, the Netherlands. 10. Department of Internal Medicine, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. 11. Department of Internal Medicine, Laurentius Hospital, Roermond, the Netherlands. 12. Department of Internal Medicine, Cà Foncello University Hospital, Treviso, Italy. 13. Department of Internal Medicine, VU Medical Center, Amsterdam, the Netherlands. 14. Department of Internal Medicine, MC Slotervaart, Amsterdam, the Netherlands. 15. Department of Internal Medicine, University Medical Center Nijmegen, Nijmegen, the Netherlands. 16. Arianna Foundation on Anticoagulation, Bologna, Italy.
Abstract
Essentials The value of compression therapy in acute phase of deep vein thrombosis is still unclear. Patients with deep vein thrombosis received acute compression hosiery, bandaging, or none. Acute compression reduces irreversible skin signs related to post thrombotic syndrome. Compression hosiery may be the preferred choice for the acute phase SUMMARY: Background The effectiveness of compression therapy in the acute phase of deep vein thrombosis (DVT) is not yet determined. Objectives To investigate the impact of compression therapy in the acute phase of DVT on determinants of the Villalta score, health-related quality of life (HRQOL), and costs. Patients/Methods Eight hundred and sixty-five patients with proximal DVT (substudy of the IDEAL DVT study) received, immediately after DVT diagnosis, either no compression, multilayer bandaging, or hosiery. In the acute phase and 3 months after diagnosis, HRQOL was determined by use of the EQ-5D, SF6D, and VEINES-QoL intrinsic method (VEINES-QoLint ). At 3 months, signs and symptoms were assessed for the total and separate items of the Villalta score, and healthcare costs were calculated. Results The compression groups had lower overall objective Villalta scores than the no-compression group (1.47 [standard deviation (SD) 1.570] and 1.59 [SD 1.64] versus 2.21 [SD 2.15]). The differences were mainly attributable to irreversible skin signs (induration, hyperpigmentation, and venectasia) and pain on calf compression. Subjective and total Villalta scores were similar across groups. Differences in HRQOL were only observed at 1 month; HRQOL was better for hosiery (EQ-5D 0.86 [SD 0.18]; VEINES-QoLint 0.66 [SD 0.18]) than for multilayer compression bandaging (EQ-5D 0.81 [SD 0.23; VEINES-QoLint 0.62 [SD 0.19]). Mean healthcare costs per patient were €417.08 (€354.10 to €489.30) for bandaging, €114.25 (€92.50 to €198.43) for hosiery, and €105.86 (€34.63 to €199.30) for no compression. Conclusions Initial compression reduces irreversible skin signs, edema, and pain on calf compression. Multilayer bandaging is slightly more effective than hosiery, but has substantially higher costs, without a gain in HRQOL. From a patient and economic perspective, compression hosiery would be preferred when initial compression is applied. TRIAL REGISTRATION: IDEAL DVT study ClinicalTrials.gov number, NCT01429714.
Essentials The value of compression therapy in acute phase of deep vein thrombosis is still unclear. Patients with deep vein thrombosis received acute compression hosiery, bandaging, or none. Acute compression reduces irreversible skin signs related to post thrombotic syndrome. Compression hosiery may be the preferred choice for the acute phase SUMMARY: Background The effectiveness of compression therapy in the acute phase of deep vein thrombosis (DVT) is not yet determined. Objectives To investigate the impact of compression therapy in the acute phase of DVT on determinants of the Villalta score, health-related quality of life (HRQOL), and costs. Patients/Methods Eight hundred and sixty-five patients with proximal DVT (substudy of the IDEAL DVT study) received, immediately after DVT diagnosis, either no compression, multilayer bandaging, or hosiery. In the acute phase and 3 months after diagnosis, HRQOL was determined by use of the EQ-5D, SF6D, and VEINES-QoL intrinsic method (VEINES-QoLint ). At 3 months, signs and symptoms were assessed for the total and separate items of the Villalta score, and healthcare costs were calculated. Results The compression groups had lower overall objective Villalta scores than the no-compression group (1.47 [standard deviation (SD) 1.570] and 1.59 [SD 1.64] versus 2.21 [SD 2.15]). The differences were mainly attributable to irreversible skin signs (induration, hyperpigmentation, and venectasia) and pain on calf compression. Subjective and total Villalta scores were similar across groups. Differences in HRQOL were only observed at 1 month; HRQOL was better for hosiery (EQ-5D 0.86 [SD 0.18]; VEINES-QoLint 0.66 [SD 0.18]) than for multilayer compression bandaging (EQ-5D 0.81 [SD 0.23; VEINES-QoLint 0.62 [SD 0.19]). Mean healthcare costs per patient were €417.08 (€354.10 to €489.30) for bandaging, €114.25 (€92.50 to €198.43) for hosiery, and €105.86 (€34.63 to €199.30) for no compression. Conclusions Initial compression reduces irreversible skin signs, edema, and pain on calf compression. Multilayer bandaging is slightly more effective than hosiery, but has substantially higher costs, without a gain in HRQOL. From a patient and economic perspective, compression hosiery would be preferred when initial compression is applied. TRIAL REGISTRATION: IDEAL DVT study ClinicalTrials.gov number, NCT01429714.
Authors: E Rabe; E Földi; H Gerlach; M Jünger; G Lulay; A Miller; K Protz; S Reich-Schupke; T Schwarz; M Stücker; E Valesky; F Pannier Journal: Hautarzt Date: 2021-02 Impact factor: 0.751
Authors: Eberhard Rabe; Hugo Partsch; Nick Morrison; Mark H Meissner; Giovanni Mosti; Christopher R Lattimer; Patrick H Carpentier; Sylvain Gaillard; Michael Jünger; Tomasz Urbanek; Juerg Hafner; Malay Patel; Stephanie Wu; Joseph Caprini; Fedor Lurie; Tobias Hirsch Journal: Phlebology Date: 2020-03-02 Impact factor: 1.740
Authors: Rachel H P Schreurs; Manuela A Joore; Daisy P De Bruijn-Geraets; Hugo Ten Cate; Arina J Ten Cate-Hoek Journal: PLoS One Date: 2022-08-08 Impact factor: 3.752
Authors: E Rabe; E Földi; H Gerlach; M Jünger; G Lulay; A Miller; K Protz; S Reich-Schupke; T Schwarz; M Stücker; E Valesky; F Pannier Journal: Hautarzt Date: 2021-01-01 Impact factor: 0.751