Elena Belloni1, Stefania Tentoni2, Mariangela Valentina Puci3, Francesco Avogliero4, Daniele Della Latta4, Simona Storti5, Baldassare Alberti6, Antonio Bottoni6, Chandra Bortolotto7, Ilaria Fiorina8, Cristina Montomoli3, Dante Chiappino4. 1. Department of Radiology, Civil Hospital, Corso Milano 19, 27029, Vigevano, Italy. belloni.elena@alice.it. 2. National Research Council, Institute of Applied Mathematics and Information Technologies "Enrico Magenes", Pavia, Italy. 3. Unit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. 4. Department of Radiology, Fondazione Toscana Gabriele Monasterio, Massa, Italy. 5. Laboratory Unit, Fondazione Toscana Gabriele Monasterio, Massa, Italy. 6. Endocrinology Unit, Fondazione Toscana Gabriele Monasterio, Massa, Italy. 7. Department of Radiology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. 8. Radiodiagnostic and Interventional Radiology Department, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Abstract
BACKGROUND: Few studies, and with conflicting results, have evaluated the potential effects of iodinated contrast media on children's thyroid function. OBJECTIVE: To investigate the effects of iodinated contrast medium on thyroid function in neonates, infants and young children with congenital heart disease undergoing cardiac computed tomography (CT). MATERIALS AND METHODS: We retrospectively evaluated 10 neonates (group 1) and 23 infants and young children (group 2) without thyroid or renal disease for serum levels of thyroid-stimulating hormone, free triiodothyronine and free thyroxine before contrast-enhanced cardiac CT, 48 h after CT and at discharge from the hospital. Cardiac CT was performed with intravenous administration of 1.14±0.17 mL/kg of body weight of iopromide (containing 370 mg of iodine/mL). RESULTS: Group 1 had a reduction of thyroid-stimulating hormone from baseline to 48 h post injection (P=0.002). Group 2 had a reduction of thyroid-stimulating hormone median levels from baseline to 48 h post injection and an increase from 48 h to discharge (P=0.0005 and P=0.0001, respectively). CONCLUSION: Intravenous iodinated contrast medium in children with congenital heart disease caused transient thyroid-stimulating hormone decrease 48 h after CT, with thyroid-stimulating hormone returning to normal range at discharge.
BACKGROUND: Few studies, and with conflicting results, have evaluated the potential effects of iodinated contrast media on children's thyroid function. OBJECTIVE: To investigate the effects of iodinated contrast medium on thyroid function in neonates, infants and young children with congenital heart disease undergoing cardiac computed tomography (CT). MATERIALS AND METHODS: We retrospectively evaluated 10 neonates (group 1) and 23 infants and young children (group 2) without thyroid or renal disease for serum levels of thyroid-stimulating hormone, free triiodothyronine and free thyroxine before contrast-enhanced cardiac CT, 48 h after CT and at discharge from the hospital. Cardiac CT was performed with intravenous administration of 1.14±0.17 mL/kg of body weight of iopromide (containing 370 mg of iodine/mL). RESULTS: Group 1 had a reduction of thyroid-stimulating hormone from baseline to 48 h post injection (P=0.002). Group 2 had a reduction of thyroid-stimulating hormone median levels from baseline to 48 h post injection and an increase from 48 h to discharge (P=0.0005 and P=0.0001, respectively). CONCLUSION: Intravenous iodinated contrast medium in children with congenital heart disease caused transient thyroid-stimulating hormone decrease 48 h after CT, with thyroid-stimulating hormone returning to normal range at discharge.
Authors: N Linder; B Sela; B German; N Davidovitch; J Kuint; J Hegesh; D Lubin; J Sack Journal: Arch Dis Child Fetal Neonatal Ed Date: 1997-11 Impact factor: 5.747
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Authors: Çağın Mustafa Üreyen; Kahraman Coşansu; Mustafa Gökhan Vural; Sait Emir Şahin; Mehmet Akif Çakar; Harun Kılıç; Mustafa Tarık Ağaç; Hüseyin Gündüz; Ramazan Akdemir; Ersan Tatlı Journal: Med Princ Pract Date: 2019-09-20 Impact factor: 1.927