Literature DB >> 2985434

Possible involvement of two proteins (phosphoprotein and CD9 (p24)) in regulation of platelet calcium fluxes.

J Enouf, R Bredoux, C Boucheix, M Mirshahi, C Soria, S Levy-Toledano.   

Abstract

The monoclonal antibody ALB6 directed against the leukocyte differentiation antigen CD9 (p24) increases the calcium incorporation into isolated platelet membrane vesicles enriched in internal membranes. The similarities of the effects of both the monoclonal antibody and the catalytic subunit of the cAMP-dependent protein kinase (C, subunit), which phosphorylates a protein of an apparent molecular mass of 23 kDa, led us to investigate the relationship between CD9 (p24) and the 23-kDa phosphoprotein (p23). ALB6IgG does not inhibit the C.subunit-induced phosphorylation of p23 and the immunoadsorption by ALB6IgG of p24 associated to membrane vesicles does not alter the phosphorylation pattern. Thus, proteins of similar molecular mass appear to be involved in calcium fluxes: one is recognized by the ALB6 antibody while the other can be phosphorylated by the C-subunit.

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Year:  1985        PMID： 2985434     DOI： 10.1016/0014-5793(85)80819-x

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  9 in total

1.  A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.

Authors:  E G Lapetina; J C Lacal; B R Reep; L Molina y Vedia
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

2.  Platelet sarco/endoplasmic reticulum Ca2+ATPase isoform 3b and Rap 1b: interrelation and regulation in physiopathology.

Authors:  C Lacabaratz-Porret; E Corvazier; T Kovàcs; R Bobe; R Bredoux; S Launay; B Papp; J Enouf
Journal:  Biochem J       Date:  1998-05-15       Impact factor: 3.857

3.  Thrombolamban, the 22-kDa platelet substrate of cyclic AMP-dependent protein kinase, is immunologically homologous with the Ras family of GTP-binding proteins.

Authors:  T E White; J C Lacal; B Reep; T H Fischer; E G Lapetina; G C White
Journal:  Proc Natl Acad Sci U S A       Date:  1990-01       Impact factor: 11.205

4.  Correlated expression of the 97 kDa sarcoendoplasmic reticulum Ca(2+)-ATPase and Rap1B in platelets and various cell lines.

Authors:  C Magnier; R Bredoux; T Kovacs; R Quarck; B Papp; E Corvazier; J de Gunzburg; J Enouf
Journal:  Biochem J       Date:  1994-01-15       Impact factor: 3.857

5.  The phosphoprotein that regulates platelet Ca2+ transport is located on the plasma membrane, controls membrane-associated Ca2(+)-ATPase and is not glycoprotein Ib beta-subunit.

Authors:  A Darnanville; R Bredoux; K J Clemetson; N Kieffer; N Bourdeau; S Levy-Toledano; J P Caen; J Enouf
Journal:  Biochem J       Date:  1991-01-15       Impact factor: 3.857

6.  Human platelets express the SERCA2-b isoform of Ca(2+)-transport ATPase.

Authors:  J Enouf; R Bredoux; B Papp; I Djaffar; A M Lompré; N Kieffer; O Gayet; K Clemetson; F Wuytack; J P Rosa
Journal:  Biochem J       Date:  1992-08-15       Impact factor: 3.857

7.  Ca2+ influx in platelets: activation by thrombin and by the depletion of the stores. Effect of cyclic nucleotides.

Authors:  M G Doni; L Cavallini; A Alexandre
Journal:  Biochem J       Date:  1994-10-15       Impact factor: 3.857

8.  Relationship between Rap1 protein phosphorylation and regulation of Ca2+ transport in platelets: a new approach.

Authors:  C Magnier; E Corvazier; M C Aumont; T H Le Jemtel; J Enouf
Journal:  Biochem J       Date:  1995-09-01       Impact factor: 3.857

9.  Evidence for a role of rap1 protein in the regulation of human platelet Ca2+ fluxes.

Authors:  E Corvazier; J Enouf; B Papp; J de Gunzburg; A Tavitian; S Levy-Toledano
Journal:  Biochem J       Date:  1992-01-15       Impact factor: 3.857
  9 in total

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