Literature DB >> 2985432

Pertussis toxin inhibits chemotactic factor-induced phospholipase C stimulation and lysosomal enzyme secretion in rabbit neutrophils.

P G Bradford, R P Rubin.   

Abstract

Pertussis toxin suppressed [32P]polyphosphoinositide breakdown and lysosomal enzyme secretion induced by fMet-Leu-Phe in rabbit neutrophils. Likewise, fMet-Leu-Phe- or leukotriene B4-evoked [3H]inositol trisphosphate accumulation was inhibited by the toxin. These findings, taken together with evidence that pertussis toxin specifically causes inactivation of the guanine nucleotide binding protein (Ni), suggests that guanine nucleotide binding proteins may mediate coupling between calcium-mobilising receptors and phospholipase C-mediated reactions in rabbit neutrophils.

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Year:  1985        PMID： 2985432     DOI： 10.1016/0014-5793(85)80801-2

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  19 in total

Review 1.  Mechanisms of calcium homeostasis in the polymorphonuclear leucocyte.

Authors:  J Westwick; C Poll
Journal:  Agents Actions       Date:  1986-10

Review 2.  Molecular basis of activation and regulation of the phagocyte respiratory burst.

Authors:  N P Hurst
Journal:  Ann Rheum Dis       Date:  1987-04       Impact factor: 19.103

3.  Activation of the human neutrophil 5-lipoxygenase by exogenous arachidonic acid: involvement of pertussis toxin-sensitive guanine nucleotide-binding proteins.

Authors:  S R McColl; E Krump; P H Naccache; A C Caon; P Borgeat
Journal:  Br J Pharmacol       Date:  1989-08       Impact factor: 8.739

Review 4.  Molecular pathogenesis, epidemiology, and clinical manifestations of respiratory infections due to Bordetella pertussis and other Bordetella subspecies.

Authors:  Seema Mattoo; James D Cherry
Journal:  Clin Microbiol Rev       Date:  2005-04       Impact factor: 26.132

5.  Relationship of phosphatidylinositol bisphosphate hydrolysis to calcium mobilization and functional activation in fluoride-treated neutrophils.

Authors:  D English; D J Debono; T G Gabig
Journal:  J Clin Invest       Date:  1987-07       Impact factor: 14.808

6.  Leukotriene B4 stimulation of phagocytes results in the formation of inositol 1,4,5-trisphosphate. A second messenger for Ca2+ mobilization.

Authors:  T Andersson; W Schlegel; A Monod; K H Krause; O Stendahl; D P Lew
Journal:  Biochem J       Date:  1986-12-01       Impact factor: 3.857

7.  Guanine nucleotide regulation of phospholipase C activity in permeabilized rabbit neutrophils. Inhibition by pertussis toxin and sensitization to submicromolar calcium concentrations.

Authors:  P G Bradford; R P Rubin
Journal:  Biochem J       Date:  1986-10-01       Impact factor: 3.857

8.  GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels.

Authors:  G G Holz; S G Rane; K Dunlap
Journal:  Nature       Date:  1986 Feb 20-26       Impact factor: 49.962

Review 9.  Chemotactic peptides. Mechanisms, functions, and possible role in inflammatory bowel disease.

Authors:  C C Nast; L E LeDuc
Journal:  Dig Dis Sci       Date:  1988-03       Impact factor: 3.199

10.  Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation.

Authors:  K H Krause; W Schlegel; C B Wollheim; T Andersson; F A Waldvogel; P D Lew
Journal:  J Clin Invest       Date:  1985-10       Impact factor: 14.808
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