| Literature DB >> 29853688 |
S Sunna Ebenesersdóttir1,2, Marcela Sandoval-Velasco3, Ellen D Gunnarsdóttir4,2, Anuradha Jagadeesan4,2, Valdís B Guðmundsdóttir4,2, Elísabet L Thordardóttir4,2, Margrét S Einarsdóttir4,2, Kristjan H S Moore4, Ásgeir Sigurðsson4, Droplaug N Magnúsdóttir4, Hákon Jónsson4, Steinunn Snorradóttir4, Eivind Hovig5,6,7, Pål Møller5,8,9, Ingrid Kockum10, Tomas Olsson10, Lars Alfredsson11, Thomas F Hansen12,13, Thomas Werge12,14,15, Gianpiero L Cavalleri16, Edmund Gilbert16, Carles Lalueza-Fox17, Joe W Walser18,19, Steinunn Kristjánsdóttir18,19, Shyam Gopalakrishnan3, Lilja Árnadóttir18, Ólafur Þ Magnússon4, M Thomas P Gilbert3,20, Kári Stefánsson1,21, Agnar Helgason1,2.
Abstract
Opportunities to directly study the founding of a human population and its subsequent evolutionary history are rare. Using genome sequence data from 27 ancient Icelanders, we demonstrate that they are a combination of Norse, Gaelic, and admixed individuals. We further show that these ancient Icelanders are markedly more similar to their source populations in Scandinavia and the British-Irish Isles than to contemporary Icelanders, who have been shaped by 1100 years of extensive genetic drift. Finally, we report evidence of unequal contributions from the ancient founders to the contemporary Icelandic gene pool. These results provide detailed insights into the making of a human population that has proven extraordinarily useful for the discovery of genotype-phenotype associations.Entities:
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Year: 2018 PMID： 29853688 DOI： 10.1126/science.aar2625
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728