| Literature DB >> 29852862 |
Zhilong Ma1, Min Chen2, Xiaohu Yang3, Bin Xu1, Zhenshun Song1, Bo Zhou1, Tingsong Yang1.
Abstract
Cancer-associated fibroblasts (CAFs) are an important cell type present in solid tumor microenvironments, including that of gastric cancer. They play a vital role in the promotion of tumorigenesis, angiogenesis, and cancer progression through paracrine signaling and modulation of the extracellular matrix. However, the exact molecular mechanism underlying the interaction between gastric cancer cells and stromal fibroblasts remains poorly understood. Recent studies have demonstrated that various factors, such as gene and microRNA variations, are involved in this process. This review discusses recent advances in understanding how these factors are regulated in CAFs and how they affect tumor biology, which may improve our understanding of their role in gastric cancer tumorigenesis and progression and provide new promising targets for therapeutic strategies. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.Entities:
Keywords: Cancer-associated fibroblasts; angiogenesis; extracellular matrix; gastric cancer; tumor microenvironment; tumorigenesis.
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Year: 2018 PMID： 29852862 DOI： 10.2174/1381612824666180601094056
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116