Literature DB >> 2985203

Postsynaptic firing during repetitive stimulation is required for long-term potentiation in hippocampus.

H E Scharfman, J M Sarvey.   

Abstract

Long-term potentiation (LTP) in the hippocampus is a long lasting enhancement of the postsynaptic evoked response following high frequency, repetitive stimulation of afferents. The extracellularly recorded action potential (population spike) can be reversibly blocked, without affecting the extracellularly recorded excitatory postsynaptic potential, by focal application of gamma-aminobutyric acid, tetrodotoxin, or pentobarbital, to the CA1 pyramidal cells of the hippocampal slice. When the population spike is blocked during repetitive stimulation, LTP does not occur. It appears that postsynaptic firing of action potentials during repetitive stimulation is necessary to produce LTP.

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Year:  1985        PMID： 2985203     DOI： 10.1016/0006-8993(85)91552-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  6 in total

1.  Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation.

Authors:  M J Thomas; A M Watabe; T D Moody; M Makhinson; T J O'Dell
Journal:  J Neurosci       Date:  1998-09-15       Impact factor: 6.167

2.  Inhibition of the production and maintenance of long-term potentiation in rat hippocampal slices by a monoclonal antibody.

Authors:  P K Stanton; J M Sarvey; J R Moskal
Journal:  Proc Natl Acad Sci U S A       Date:  1987-03       Impact factor: 11.205

3.  Structural and functional asymmetry in the normal and epileptic rat dentate gyrus.

Authors:  Helen E Scharfman; Anne L Sollas; Karen L Smith; Meyer B Jackson; Jeffrey H Goodman
Journal:  J Comp Neurol       Date:  2002-12-23       Impact factor: 3.215

4.  Brief exposure to the G-protein activator NaF/AlCl3 induces prolonged enhancement of synaptic transmission in area CAl of rat hippocampal slices.

Authors:  S J Publicover
Journal:  Exp Brain Res       Date:  1991       Impact factor: 1.972

5.  Effects of adrenocortical steroids on long-term potentiation in the limbic system: basic mechanisms and behavioral consequences.

Authors:  B Dubrovsky; K Gijsbers; D Filipini; M K Birmingham
Journal:  Cell Mol Neurobiol       Date:  1993-08       Impact factor: 5.046

6.  Temporal modulation of spike-timing-dependent plasticity.

Authors:  Robert C Froemke; Dominique Debanne; Guo-Qiang Bi
Journal:  Front Synaptic Neurosci       Date:  2010-06-17
  6 in total

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